{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T21:58:40Z","timestamp":1785189520312,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,8,10]],"date-time":"2017-08-10T00:00:00Z","timestamp":1502323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>We assessed the prevalence and magnitude of neuropsychiatric adverse events (<jats:styled-content style=\"fixed-case\">NPAE<\/jats:styled-content>s) associated with antiepileptic drugs (<jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>s) among patients with brain tumour\u2010related epilepsy (<jats:styled-content style=\"fixed-case\">BTRE<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This observational, prospective, multicentre study enrolled 259 patients with <jats:styled-content style=\"fixed-case\">BTRE<\/jats:styled-content> after neurosurgery. All patients received <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content> monotherapy. Efficacy was assessed through clinical diaries, whereas <jats:styled-content style=\"fixed-case\">NPAE<\/jats:styled-content>s were collected using the Neuropsychiatric Inventory Test\u201012 questionnaire at baseline and after 5 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Tumour localization in the frontal lobe was associated with a higher prevalence of <jats:styled-content style=\"fixed-case\">NPAE<\/jats:styled-content>s (odds ratio, 7.73; <jats:italic>P<\/jats:italic> &lt; 0.001). Independent of tumour localization, levetiracetam (<jats:styled-content style=\"fixed-case\">LVT)<\/jats:styled-content> treatment was associated with higher prevalence and magnitude of <jats:styled-content style=\"fixed-case\">NPAE<\/jats:styled-content>s (odds ratio, 7.94; <jats:italic>P<\/jats:italic> &lt; 0.01) compared with other <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>s. Patients with oligodendroglioma reported more <jats:styled-content style=\"fixed-case\">NPAE<\/jats:styled-content>s than patients with other tumour types. <jats:styled-content style=\"fixed-case\">NPAE<\/jats:styled-content>s were not influenced by chemotherapy, radiotherapy or steroid treatment. Evaluating non\u2010neurobehavioural adverse events of <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>s, no significant differences were found among <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>s, although patients treated with old <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>s had a higher prevalence of adverse events than those treated with new <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both tumour localization in the frontal lobe and <jats:styled-content style=\"fixed-case\">LVT<\/jats:styled-content> treatment are associated with a higher risk of <jats:styled-content style=\"fixed-case\">NPAE<\/jats:styled-content>s in patients with <jats:styled-content style=\"fixed-case\">BTRE<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">LVT<\/jats:styled-content> is regarded as a first\u2010line option in patients with <jats:styled-content style=\"fixed-case\">BTRE<\/jats:styled-content> because of easy titration and few significant drug\u2010to\u2010drug interactions. Thus, as <jats:styled-content style=\"fixed-case\">NPAE<\/jats:styled-content>s lead to poor compliance and a high dropout rate, clinicians need to accurately monitor <jats:styled-content style=\"fixed-case\">NPAE<\/jats:styled-content>s after <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content> prescription, especially in patients with frontal lobe tumours receiving <jats:styled-content style=\"fixed-case\">LVT<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13375","type":"journal-article","created":{"date-parts":[[2017,8,10]],"date-time":"2017-08-10T11:17:17Z","timestamp":1502363837000},"page":"1283-1289","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Neuropsychiatric adverse events of antiepileptic drugs in brain tumour\u2010related epilepsy: an Italian multicentre prospective observational 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