{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T09:47:02Z","timestamp":1770976022640,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,14]],"date-time":"2017-12-14T00:00:00Z","timestamp":1513209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Identification of patients with familial hypercholesterolaemia (<jats:styled-content style=\"fixed-case\">FH<\/jats:styled-content>) is a prerequisite for the appropriate management of their excess cardiovascular risk. It is currently unknown how many patients with acute ischaemic stroke or transient ischaemic attack (<jats:styled-content style=\"fixed-case\">TIA<\/jats:styled-content>) are affected by <jats:styled-content style=\"fixed-case\">FH<\/jats:styled-content> and whether systematic screening for <jats:styled-content style=\"fixed-case\">FH<\/jats:styled-content> is warranted in these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The prevalence of a clinical diagnosis of <jats:styled-content style=\"fixed-case\">FH<\/jats:styled-content> was estimated in a large representative series of patients with acute ischaemic stroke or <jats:styled-content style=\"fixed-case\">TIA<\/jats:styled-content> (ABCD2 score\u00a0\u2265\u00a03) using the Dutch Lipid Clinic Network Algorithm (<jats:styled-content style=\"fixed-case\">DLCNA<\/jats:styled-content>; possible <jats:styled-content style=\"fixed-case\">FH<\/jats:styled-content>\u00a0\u22653, probable\/definite <jats:styled-content style=\"fixed-case\">FH<\/jats:styled-content>\u00a0\u22656).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 1054 patients included in the present analysis, 14 had probable\/definite <jats:styled-content style=\"fixed-case\">FH<\/jats:styled-content> (1.3%; 95% confidence interval 0.6\u20132.0) and 107 possible <jats:styled-content style=\"fixed-case\">FH<\/jats:styled-content> (10.2%; 8.4\u201312.0) corresponding to an overall prevalence of potential <jats:styled-content style=\"fixed-case\">FH<\/jats:styled-content> of 11.5%. Prevalences were even higher in patients with stroke\/<jats:styled-content style=\"fixed-case\">TIA<\/jats:styled-content> manifestation before age 55 in men or 60 in women (3.1%, 0.6\u20135.6; and 13.1%, 8.3\u201317.9) and those with a prior history of cardiovascular disease (2.6%, 0.9\u20134.3; and 15.1%, 11.3\u201318.9). Of note, in two\u2010thirds of our patients with probable\/definite and possible <jats:styled-content style=\"fixed-case\">FH<\/jats:styled-content>, stroke or <jats:styled-content style=\"fixed-case\">TIA<\/jats:styled-content> was the initial clinical disease manifestation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The frequency of potential <jats:styled-content style=\"fixed-case\">FH<\/jats:styled-content>, based on clinical criteria, in patients with acute ischaemic stroke or <jats:styled-content style=\"fixed-case\">TIA<\/jats:styled-content> was 11.5% and that of probable\/definite <jats:styled-content style=\"fixed-case\">FH<\/jats:styled-content> (1.3%) was similar to recently reported counts for patients with acute coronary syndrome (1.6%). <jats:styled-content style=\"fixed-case\">FH<\/jats:styled-content> screening using the <jats:styled-content style=\"fixed-case\">DLCNA<\/jats:styled-content> is feasible in clinical routine and should be considered as part of the usual diagnostic work\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13485","type":"journal-article","created":{"date-parts":[[2017,10,20]],"date-time":"2017-10-20T20:00:37Z","timestamp":1508529637000},"page":"260-267","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Familial hypercholesterolaemia in patients with ischaemic stroke or transient ischaemic attack"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8168-2837","authenticated-orcid":false,"given":"T.","family":"Toell","sequence":"first","affiliation":[{"name":"Department of Neurology Medical University of Innsbruck Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Mayer","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Innsbruck Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Pechlaner","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Innsbruck Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Krebs","sequence":"additional","affiliation":[{"name":"Department of Neurology Hospital Barmherzige Brueder Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Willeit","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Innsbruck Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Lang","sequence":"additional","affiliation":[{"name":"Department of Neurology Hospital Barmherzige Brueder Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Boehme","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Innsbruck Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Prantl","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Innsbruck Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Knoflach","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Innsbruck Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Department of Neurology Hospital Barmherzige Brueder Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Fuchs","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Innsbruck Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Prokop","sequence":"additional","affiliation":[{"name":"Central Institute of Medical and Chemical Laboratory Diagnostics University Hospital of Innsbruck Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Griesmacher","sequence":"additional","affiliation":[{"name":"Central Institute of Medical and Chemical Laboratory Diagnostics University Hospital of Innsbruck Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Lang","sequence":"additional","affiliation":[{"name":"Department of Neurology Hospital Barmherzige Brueder Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Kiechl","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Innsbruck Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Willeit","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Innsbruck Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw028"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht273"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv602"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2015.08.038"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60771-5"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2003.11.010"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv289"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60150-0"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003033"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70286-8"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.326.7404.1423"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1368-5031.2004.00289.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0b013e318296aeca"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.24.1.35"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.25.11.2220"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.19.5.604"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw272"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2016.03.023"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-1331.1999.660691.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.17.6.1142"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.19.9.1097"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000047123.14312.3E"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2015.04.016"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2004.12.001"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2016.08.037"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fene.13485","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.13485","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ene.13485","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.13485","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T00:51:25Z","timestamp":1693356685000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.13485"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,14]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1111\/ene.13485"],"URL":"https:\/\/doi.org\/10.1111\/ene.13485","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,14]]},"assertion":[{"value":"2017-07-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-10-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-12-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}