{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T03:16:28Z","timestamp":1768878988855,"version":"3.49.0"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,6]],"date-time":"2017-12-06T00:00:00Z","timestamp":1512518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Lithuania is one of the countries with the highest incidence of tick\u2010borne encephalitis (<jats:styled-content style=\"fixed-case\">TBE<\/jats:styled-content>) in Europe. The aim of this study was to describe the epidemiological patterns of <jats:styled-content style=\"fixed-case\">TBE<\/jats:styled-content> in Lithuania, and characterize clinical features in adults in the light of the high incidence in recent years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Surveillance data available on the website of the Centre for Communicable Diseases and <jats:styled-content style=\"fixed-case\">AIDS<\/jats:styled-content> of Lithuania were used to describe the epidemiological patterns of <jats:styled-content style=\"fixed-case\">TBE<\/jats:styled-content>. The retrospective study included 712 patients hospitalized in the Centre for Infectious Diseases and the Centre for Neurology of Vilnius University in the years 2005\u20132014.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Tick\u2010borne encephalitis incidence rates have been increasing by 8.5% per year for the 45\u2010year period from 1970 to 2014. The joinpoint model finds two joinpoints at 1991 and 1994, with a significant decrease of 8.4% per year (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) prior to the joinpoint at 1991, and a rise of 195.2% afterwards. <jats:styled-content style=\"fixed-case\">TBE<\/jats:styled-content> presented with meningoencephalitis in 556 cases (81.3%). A total of 129 patients (18%) had a severe case of the disease. The most common neurological signs were ataxia (579, 81.3%), meningeal signs (474, 66.5%) and tremor (338, 47.5%). Limb paresis was observed in 6.3% of patients. Five patients (0.7%) died, and 544 patients (76.7%) were discharged with sequelae.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Intensified efforts in promoting <jats:styled-content style=\"fixed-case\">TBE<\/jats:styled-content> vaccination will be needed in the light of the high incidence and expanded spatial distribution. Significant prognostic factors for severe cases of the disease were age above 61 and delayed immune response of specific immunoglobulin G.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13486","type":"journal-article","created":{"date-parts":[[2017,10,20]],"date-time":"2017-10-20T20:00:44Z","timestamp":1508529644000},"page":"268-274","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Epidemiological patterns of tick\u2010borne encephalitis in Lithuania and clinical features in adults in the light of the high incidence in recent years: a retrospective study"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1599-2973","authenticated-orcid":false,"given":"D.","family":"Radzi\u0161auskien\u0117","sequence":"first","affiliation":[{"name":"Department of Infectious, Chest Diseases, Dermatovenerology and Allergology Vilnius University Vilnius 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