{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T02:36:26Z","timestamp":1776134186244,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,11]],"date-time":"2017-12-11T00:00:00Z","timestamp":1512950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81400946"],"award-info":[{"award-number":["81400946"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81601017"],"award-info":[{"award-number":["81601017"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Clinical trials have shown that robust collateral flow has a relationship with good clinical outcome; however, different stroke subtypes were lumped together. This study explored the relationship between baseline collaterals and the onset\u2010to\u2010imaging time (<jats:styled-content style=\"fixed-case\">OIT<\/jats:styled-content>) and the correlation between pre\u2010treatment collateral status and clinical outcome amongst different subtypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Prospectively collected data from consecutive acute ischaemic stroke patients with acute middle cerebral artery occlusion who received reperfusion therapy were reviewed. The regional leptomeningeal score (20 points) was based on the scoring extent of contrast opacification in the six Alberta Stroke Program Early CT Score (<jats:styled-content style=\"fixed-case\">ASPECTS<\/jats:styled-content>) cortical regions (M1\u20136), parasagittal anterior cerebral artery territory and the basal ganglia by perfusion\u2010derived dynamic four\u2010dimensional computed tomography angiography (4D <jats:styled-content style=\"fixed-case\">CTA<\/jats:styled-content>). Stroke subtype was determined by the <jats:styled-content style=\"fixed-case\">TOAST<\/jats:styled-content> classification criteria. A 3\u2010months modified Rankin Scale score of 0\u20132 was defined as a good outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The analysis included 158 patients: 30 (19.0%) patients had large artery atherosclerotic stroke (LAA), 87 (55.1%) cardioembolic stroke (<jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content>) and 41 (25.9%) stroke of undetermined etiology. Baseline collateral was negatively correlated with <jats:styled-content style=\"fixed-case\">OIT<\/jats:styled-content> (<jats:italic>P<\/jats:italic> = 0.0205) in the <jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content> group after adjusting for female sex, smoking, hyperlipidemia, baseline National Institutes of Health Stroke Scale (<jats:styled-content style=\"fixed-case\">NIHSS<\/jats:styled-content>) and baseline mismatch ratio, but not in the <jats:styled-content style=\"fixed-case\">LAA<\/jats:styled-content> group. Baseline collateral showed a strong relationship with good clinical outcome after adjusting for recanalization, baseline <jats:styled-content style=\"fixed-case\">NIHSS<\/jats:styled-content>, age and female sex (odds ratio 1.120, confidence interval 1.013\u20131.238, <jats:italic>P<\/jats:italic> = 0.027) in all patients and in the <jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content> group (odds ratio 3.223, confidence interval 1.212\u20138.570, <jats:italic>P<\/jats:italic> = 0.019), but not in the <jats:styled-content style=\"fixed-case\">LAA<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Based on 4D <jats:styled-content style=\"fixed-case\">CTA<\/jats:styled-content>, sustained good leptomeningeal collaterals may predict good outcome in <jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content> but not in <jats:styled-content style=\"fixed-case\">LAA<\/jats:styled-content> patients. Moreover, the extent of collaterals was associated with <jats:styled-content style=\"fixed-case\">OIT<\/jats:styled-content> in the <jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content> patients, which indicates prompt reperfusion therapy in this group of patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13493","type":"journal-article","created":{"date-parts":[[2017,10,20]],"date-time":"2017-10-20T21:37:47Z","timestamp":1508535467000},"page":"293-300","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Distinct predictive role of collateral status on clinical outcome in variant stroke subtypes of acute large arterial occlusion"],"prefix":"10.1111","volume":"25","author":[{"given":"X.","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neurology School of Medicine Second Affiliated Hospital of Zhejiang University Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9588-2733","authenticated-orcid":false,"given":"M.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology School of Medicine Second Affiliated Hospital of Zhejiang University Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Radiology School of Medicine Second Affiliated Hospital of Zhejiang University Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6425-0672","authenticated-orcid":false,"given":"S.","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Neurology School of Medicine Second Affiliated Hospital of Zhejiang University Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. 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