{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T06:08:14Z","timestamp":1789538894851,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,18]],"date-time":"2017-12-18T00:00:00Z","timestamp":1513555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["N_CUHK421\/16"],"award-info":[{"award-number":["N_CUHK421\/16"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005153","name":"China National Funds for Distinguished Young Scientists","doi-asserted-by":"publisher","award":["81601000"],"award-info":[{"award-number":["81601000"]}],"id":[{"id":"10.13039\/501100005153","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background and purpose<\/jats:title>\n                    <jats:p>\n                      Leptomeningeal collateral (\n                      <jats:styled-content style=\"fixed-case\">LMC<\/jats:styled-content>\n                      ) status governs the prognosis of large artery occlusive stroke, although factors determining\n                      <jats:styled-content style=\"fixed-case\">LMC<\/jats:styled-content>\n                      status are not fully elucidated. The aim was to investigate metrics affecting\n                      <jats:styled-content style=\"fixed-case\">LMC<\/jats:styled-content>\n                      status in such patients by using computational fluid dynamics (\n                      <jats:styled-content style=\"fixed-case\">CFD<\/jats:styled-content>\n                      ) models based on computed tomography angiography (\n                      <jats:styled-content style=\"fixed-case\">CTA<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this cross\u2010sectional study, patients with recent ischaemic stroke or transient ischaemic attack attributed to atherosclerotic M1 middle cerebral artery (\n                      <jats:styled-content style=\"fixed-case\">MCA<\/jats:styled-content>\n                      ) stenosis (50%\u201399%) were recruited. Demographic, clinical and imaging data of these patients were collected. Ipsilesional\n                      <jats:styled-content style=\"fixed-case\">LMC<\/jats:styled-content>\n                      status was graded as good or poor by assessing the laterality of anterior and posterior cerebral arteries in\n                      <jats:styled-content style=\"fixed-case\">CTA<\/jats:styled-content>\n                      . A\n                      <jats:styled-content style=\"fixed-case\">CFD<\/jats:styled-content>\n                      model based on\n                      <jats:styled-content style=\"fixed-case\">CTA<\/jats:styled-content>\n                      was constructed to reflect focal hemodynamics in the distal internal carotid artery, M1\n                      <jats:styled-content style=\"fixed-case\">MCA<\/jats:styled-content>\n                      and A1 anterior cerebral artery. Pressure gradients were calculated across culprit\n                      <jats:styled-content style=\"fixed-case\">MCA<\/jats:styled-content>\n                      stenotic lesions in\n                      <jats:styled-content style=\"fixed-case\">CFD<\/jats:styled-content>\n                      models. Predictors for good\n                      <jats:styled-content style=\"fixed-case\">LMC<\/jats:styled-content>\n                      status were sought in univariate and multivariate analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Amongst the 85 patients enrolled (mean age 61.5 \u00b1 10.9 years), 38 (44.7%) had good ipsilesional\n                      <jats:styled-content style=\"fixed-case\">LMC<\/jats:styled-content>\n                      status. The mean pressure gradient across\n                      <jats:styled-content style=\"fixed-case\">MCA<\/jats:styled-content>\n                      lesions was 14.8 \u00b1 18.1 mmHg. Advanced age (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.030) and a larger translesional pressure gradient (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.029) independently predicted good\n                      <jats:styled-content style=\"fixed-case\">LMC<\/jats:styled-content>\n                      s. A lower fasting blood glucose level also showed a trend for good\n                      <jats:styled-content style=\"fixed-case\">LMC<\/jats:styled-content>\n                      s (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.058).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Our study suggested a correlation between translesional pressure gradient and maturation of\n                      <jats:styled-content style=\"fixed-case\">LMC<\/jats:styled-content>\n                      s in intracranial atherosclerotic disease. Further studies with more exquisite and dynamic monitoring of cerebral hemodynamics and\n                      <jats:styled-content style=\"fixed-case\">LMC<\/jats:styled-content>\n                      evolution are needed to verify the current findings.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.13521","type":"journal-article","created":{"date-parts":[[2017,11,24]],"date-time":"2017-11-24T02:32:45Z","timestamp":1511490765000},"page":"404-410","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Translesional pressure gradient and leptomeningeal collateral status in symptomatic middle cerebral artery stenosis"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7300-6647","authenticated-orcid":false,"given":"X.","family":"Leng","sequence":"first","affiliation":[{"name":"Division of Neurology Department of Medicine and Therapeutics Chinese University of Hong Kong, Prince of Wales Hospital Hong Kong China"},{"name":"Shenzhen Research Institute Chinese University of Hong Kong Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Lan","sequence":"additional","affiliation":[{"name":"Division of Neurology Department of Medicine and Therapeutics Chinese University of Hong Kong, Prince of Wales Hospital Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. L.","family":"Ip","sequence":"additional","affiliation":[{"name":"Division of Neurology Department of Medicine and Therapeutics Chinese University of Hong Kong, Prince of Wales Hospital Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Fan","sequence":"additional","affiliation":[{"name":"Division of Neurology Department of Medicine and Therapeutics Chinese University of Hong Kong, Prince of Wales Hospital Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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