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Seventeen patients had brain abnormalities (89.5%), of which eight (42.1%) revealed the characteristic radial enhancing and laminar patterns. Cortical abnormalities were found in four patients (21.1%). Other abnormalities were found in the hypothalamus, midbrain, pons, medulla cerebellum, meninges and skull. Eleven patients had longitudinally extensive spinal cord lesions.<jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content>abnormalities were detected in all patients. Pathological examinations of four patients revealed extensive inflammation, with prominent perivascular B cells and T cells. Abundant antibody\u2010secreting cells were noted in the interstitial and perivascular spaces. Immunohistochemical analysis showed loss of astrocytes and neurons.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present patients with positive<jats:styled-content style=\"fixed-case\">GFAP<\/jats:styled-content>\u2010immunoglobulin G are highly similar to autoimmune<jats:styled-content style=\"fixed-case\">GFAP<\/jats:styled-content>astrocytopathy, described in a recent report. The features of the neuropathology and immunopathology of<jats:styled-content style=\"fixed-case\">GFAP<\/jats:styled-content>astrocytopathies were perivascular inflammation and loss of astrocytes and neurons.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13531","type":"journal-article","created":{"date-parts":[[2017,11,29]],"date-time":"2017-11-29T17:37:28Z","timestamp":1511977048000},"page":"477-483","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":192,"title":["Autoimmune glial fibrillary acidic protein astrocytopathy in Chinese patients: a retrospective study"],"prefix":"10.1111","volume":"25","author":[{"given":"Y.","family":"Long","sequence":"first","affiliation":[{"name":"Department of Neurology Second Affiliated Hospital of Guangzhou Medical University Guangzhou China"},{"name":"Institute of Neuroscience Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province Ministry of Education of China Collaborative 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