{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T11:10:39Z","timestamp":1776510639032,"version":"3.51.2"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,1,13]],"date-time":"2018-01-13T00:00:00Z","timestamp":1515801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["320030_173153"],"award-info":[{"award-number":["320030_173153"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>This cross\u2010sectional study aims to compare gait changes after the cerebrospinal fluid (<jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content>) tap test between normal pressure hydrocephalus patients with and without brain comorbidities (<jats:styled-content style=\"fixed-case\">NPH<\/jats:styled-content>+ and <jats:styled-content style=\"fixed-case\">NPH<\/jats:styled-content>\u2212 respectively) and then to identify significant contributors to a poor <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> tap test amongst individuals with <jats:styled-content style=\"fixed-case\">NPH<\/jats:styled-content>+.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Gait changes (during the single task and the dual task of backward counting) were quantified before and 24 h after the <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> tap test with an optoelectronic system in 52 <jats:styled-content style=\"fixed-case\">NPH<\/jats:styled-content> patients (77.4 \u00b1 6.0 years; 34.6% women). Changes after the <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> tap test in stride time variability (<jats:styled-content style=\"fixed-case\">STV<\/jats:styled-content>, %) were our main outcome. <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> Alzheimer's disease biomarkers, cerebrovascular white matter changes assessed with brain imaging and neurodegenerative diseases with parkinsonian syndrome represented the three individual brain comorbidities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Brain comorbidities were frequently identified, <jats:styled-content style=\"fixed-case\">NPH<\/jats:styled-content>+ patients representing 40 patients of our sample (76.9%). <jats:styled-content style=\"fixed-case\">NPH<\/jats:styled-content>\u2212 patients improved their <jats:styled-content style=\"fixed-case\">STV<\/jats:styled-content> better in the single task (delta of <jats:styled-content style=\"fixed-case\">STV<\/jats:styled-content> = \u221258.6% \u00b1 54.3% vs. \u221214.1% \u00b1 62.0%; <jats:italic>P<\/jats:italic> = 0.031) and in the dual task (delta of <jats:styled-content style=\"fixed-case\">STV<\/jats:styled-content> =\u221232.2% \u00b1 33.7% vs. 6.3% \u00b1 58.4%; <jats:italic>P<\/jats:italic> = 0.028) after the <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> tap test than <jats:styled-content style=\"fixed-case\">NPH<\/jats:styled-content>+ patients. Amongst <jats:styled-content style=\"fixed-case\">NPH<\/jats:styled-content>+ individuals, only comorbid Alzheimer's disease was associated with <jats:styled-content style=\"fixed-case\">STV<\/jats:styled-content> increase (i.e. deterioration of gait) in the dual task [<jats:italic>\u03b2<\/jats:italic> 38.4; 95% confidence interval (5.64; 71.24); <jats:italic>P<\/jats:italic> = 0.023] after the <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> tap test, whilst it was borderline in the single task [<jats:italic>\u03b2<\/jats:italic> 35.0; 95% confidence interval (\u22121.97; 71.90); <jats:italic>P<\/jats:italic> = 0.063].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Brain comorbidities affect gait improvement after the <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> tap test in <jats:styled-content style=\"fixed-case\">NPH<\/jats:styled-content> patients; this influence is driven by Alzheimer's disease\u2010related pathology.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13543","type":"journal-article","created":{"date-parts":[[2017,12,9]],"date-time":"2017-12-09T18:36:46Z","timestamp":1512844606000},"page":"542-548","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Brain comorbidities in normal pressure hydrocephalus"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4455-6719","authenticated-orcid":false,"given":"G.","family":"Allali","sequence":"first","affiliation":[{"name":"Department of Clinical Neurosciences Division of Neurology Geneva University Hospitals and Faculty of Medicine University of Geneva Geneva Switzerland"},{"name":"Department of Neurology Division of Cognitive and Motor Aging Albert Einstein College of Medicine Yeshiva University Bronx NY 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