{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T21:47:22Z","timestamp":1774734442641,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,2,16]],"date-time":"2018-02-16T00:00:00Z","timestamp":1518739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571247"],"award-info":[{"award-number":["81571247"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>The aim of this study was to address the vascular depression hypothesis in Parkinson's disease (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>) from a large cohort of Chinese population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional analysis of 1784 Chinese patients with <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> was conducted. Patients were divided into absence of depression (score \u2264 20) and presence of depression (score &gt; 20) based on assessment of the Hamilton Depression Rating Scale. Other clinical assessments included the Unified <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> Rating Scale (<jats:styled-content style=\"fixed-case\">UPDRS<\/jats:styled-content>), the Hamilton Anxiety Rating Scale, the frontal assessment battery (<jats:styled-content style=\"fixed-case\">FAB<\/jats:styled-content>) and the Montreal Cognitive Assessment (Mo<jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with depression showed a higher proportion of women, longer disease duration, higher <jats:styled-content style=\"fixed-case\">UPDRS<\/jats:styled-content> part <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> score, higher levodopa equivalent daily dose use, higher occurrences of motor fluctuation and dyskinesia, lower <jats:styled-content style=\"fixed-case\">FAB<\/jats:styled-content> score and lower Mo<jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content> score than those without depression (<jats:italic>P<\/jats:italic> &lt; 0.05). The proportions of drinking and overweight\/obesity in the depression group were significantly lower than those in the non\u2010depression group (<jats:italic>P<\/jats:italic> &lt; 0.05). A forward binary logistic regression model indicated that depression in <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> was associated with female sex [odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) 1.376, <jats:italic>P<\/jats:italic> = 0.025], higher <jats:styled-content style=\"fixed-case\">UPDRS<\/jats:styled-content> part <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> score (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.042, <jats:italic>P<\/jats:italic> &lt; 0.001), lower <jats:styled-content style=\"fixed-case\">FAB<\/jats:styled-content> score (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 0.937, <jats:italic>P<\/jats:italic> = 0.015), anxiety (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 18.156, <jats:italic>P<\/jats:italic> &lt; 0.001) and overweight\/obesity (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 0.700, <jats:italic>P<\/jats:italic> = 0.019), whereas no associations were found with hypertension, diabetes, smoking, drinking, hyperlipidaemia and heart disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study failed to verify the vascular depression hypothesis in <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>. On the contrary, it was demonstrated that overweight\/obesity is negatively associated with the presence of depression in <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13551","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T09:01:04Z","timestamp":1514106064000},"page":"637-643","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Vascular risk factors and depression in Parkinson's disease"],"prefix":"10.1111","volume":"25","author":[{"given":"R.","family":"Ou","sequence":"first","affiliation":[{"name":"Department of Neurology West China Hospital Sichuan University Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q.","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Neurology West China Hospital Sichuan University Chengdu Sichuan 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