{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T18:25:58Z","timestamp":1771611958002,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T00:00:00Z","timestamp":1517875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008793","name":"Universidad del Rosario","doi-asserted-by":"publisher","award":["ABN011"],"award-info":[{"award-number":["ABN011"]}],"id":[{"id":"10.13039\/501100008793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007637","name":"Departamento Administrativo de Ciencia, Tecnolog\u00eda e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["747\u20102016"],"award-info":[{"award-number":["747\u20102016"]}],"id":[{"id":"10.13039\/100007637","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Zika virus (<jats:styled-content style=\"fixed-case\">ZIKV<\/jats:styled-content>) infection has been associated with an increased incidence of Guillain\u2212Barr\u00e9 syndrome (<jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content>) but the relative frequency of acute inflammatory demyelinating polyradiculoneuropathy (<jats:styled-content style=\"fixed-case\">AIDP<\/jats:styled-content>) and axonal <jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content> subtypes is controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty <jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content> patients diagnosed according to the Brighton criteria during the <jats:styled-content style=\"fixed-case\">ZIKV<\/jats:styled-content> outbreak in C\u00facuta, Colombia, were evaluated clinically and electrophysiologically. The electrodiagnosis of <jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content> subtypes was made according to a recently described criteria set that demonstrated a high diagnostic accuracy on the basis of a single test. The electrophysiological features of 34 Italian <jats:styled-content style=\"fixed-case\">AIDP<\/jats:styled-content> patients were used as control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All patients had symptoms compatible with <jats:styled-content style=\"fixed-case\">ZIKV<\/jats:styled-content> infection before the onset of <jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ZIKV<\/jats:styled-content> infection was laboratory confirmed through a plaque reduction neutralization test (<jats:styled-content style=\"fixed-case\">PRNT<\/jats:styled-content><jats:sub>90<\/jats:sub>) in 100% of patients. The median time from onset of <jats:styled-content style=\"fixed-case\">ZIKV<\/jats:styled-content> infection symptoms to <jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content> was 5 days (interquartile range 1\u20136 days). Cranial nerve palsy was present in 85% of patients (facial palsy in 75%, bulbar nerve involvement in 60%), autonomic dysfunction in 85%, and 50% of patients required invasive mechanical ventilation. <jats:styled-content style=\"fixed-case\">AIDP<\/jats:styled-content> was diagnosed in 70% of patients. 40% of nerves of <jats:styled-content style=\"fixed-case\">AIDP<\/jats:styled-content> patients showed a prevalent distal demyelinating involvement but this pattern was not different from the Italian <jats:styled-content style=\"fixed-case\">AIDP<\/jats:styled-content> patients without <jats:styled-content style=\"fixed-case\">ZIKV<\/jats:styled-content> infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Guillain\u2212Barr\u00e9 syndrome associated with <jats:styled-content style=\"fixed-case\">ZIKV<\/jats:styled-content> infection in C\u00facuta is characterized by a high frequency of cranial nerve involvement, autonomic dysfunction and requirement of mechanical ventilation indicating an aggressive and severe course. <jats:styled-content style=\"fixed-case\">AIDP<\/jats:styled-content> is the most frequent electrophysiological subtype. Demyelination is prevalent distally but this pattern is not specific for <jats:styled-content style=\"fixed-case\">ZIKV<\/jats:styled-content> infection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13552","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T06:41:37Z","timestamp":1513924897000},"page":"644-650","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Clinical and nerve conduction features in Guillain\u2212Barr\u00e9 syndrome associated with Zika virus infection in C\u00facuta, Colombia"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8131-8912","authenticated-orcid":false,"given":"A.","family":"Uncini","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Imaging and Clinical Sciences University \u2018G. d'Annunzio\u2019 Chieti\u2010Pescara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. C.","family":"Gonz\u00e1lez\u2010Bravo","sequence":"additional","affiliation":[{"name":"Center for Autoimmune Diseases Research (CREA) School of Medicine and Health Sciences Universidad del Rosario Bogot\u00e1 Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y. Y.","family":"Acosta\u2010Ampudia","sequence":"additional","affiliation":[{"name":"Center for Autoimmune Diseases Research (CREA) School of Medicine and Health Sciences Universidad del Rosario Bogot\u00e1 Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. 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