{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:01:35Z","timestamp":1791820895593,"version":"4.3.4"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T00:00:00Z","timestamp":1516752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Serum neurofilaments are markers of axonal injury. We addressed their diagnostic and prognostic role in acute ischemic stroke (<jats:styled-content style=\"fixed-case\">AIS<\/jats:styled-content>) and transient ischemic attack (<jats:styled-content style=\"fixed-case\">TIA<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nested within a prospective cohort study, we compared levels of serum neurofilament light chain (<jats:styled-content style=\"fixed-case\">sNfL<\/jats:styled-content>) drawn within 24 h from symptom onset in patients with <jats:styled-content style=\"fixed-case\">AIS<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">TIA<\/jats:styled-content>. Patients without magnetic resonance imaging on admission were excluded. We assessed whether <jats:styled-content style=\"fixed-case\">sNfL<\/jats:styled-content> was associated with: (i) clinical severity on admission, (ii) diagnosis of <jats:styled-content style=\"fixed-case\">AIS<\/jats:styled-content> vs. <jats:styled-content style=\"fixed-case\">TIA<\/jats:styled-content>, (iii) infarct size on admission magnetic resonance diffusion\u2010weighted imaging (<jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DWI<\/jats:styled-content>) and (iv) functional outcome at 3 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We analyzed 504 patients with <jats:styled-content style=\"fixed-case\">AIS<\/jats:styled-content> and 111 patients with <jats:styled-content style=\"fixed-case\">TIA<\/jats:styled-content>. On admission, higher National Institutes of Health Stroke Scale (<jats:styled-content style=\"fixed-case\">NIHSS<\/jats:styled-content>) scores were associated with higher <jats:styled-content style=\"fixed-case\">sNfL<\/jats:styled-content>:<jats:styled-content style=\"fixed-case\"> NIHSS score<\/jats:styled-content> &lt; 7, 13.1 pg\/mL [interquartile range (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>), 5.3\u201327.8]; <jats:styled-content style=\"fixed-case\">NIHSS score<\/jats:styled-content> 7\u201315, 16.7 pg\/mL (IQR, 7.4\u201334.9); and <jats:styled-content style=\"fixed-case\">NIHSS score <\/jats:styled-content>&gt; 15, 21.0 pg\/mL (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>, 9.3\u201340.4) (<jats:italic>P<\/jats:italic> = 0.01). Compared with <jats:styled-content style=\"fixed-case\">AIS<\/jats:styled-content>, patients with <jats:styled-content style=\"fixed-case\">TIA<\/jats:styled-content> had lower <jats:styled-content style=\"fixed-case\">sNfL<\/jats:styled-content> levels [9.0 pg\/mL (95% confidence interval, 4.0\u201319.0) vs. 16.0 pg\/mL (95% confidence interval, 7.3\u201334.4), <jats:italic>P<\/jats:italic> &lt; 0.001], also after adjusting for age and <jats:styled-content style=\"fixed-case\">NIHSS<\/jats:styled-content> score (<jats:italic>P<\/jats:italic> = 0.006). Among patients with <jats:styled-content style=\"fixed-case\">AIS<\/jats:styled-content>, infarct size on admission <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DWI<\/jats:styled-content> was not associated with <jats:styled-content style=\"fixed-case\">sNfL<\/jats:styled-content>, either in univariate analysis (<jats:italic>P<\/jats:italic> = 0.15) or after adjusting for age and <jats:styled-content style=\"fixed-case\">NIHSS<\/jats:styled-content> score on admission (<jats:italic>P<\/jats:italic> = 0.56). Functional outcome 3 months after stroke was not associated with <jats:styled-content style=\"fixed-case\">sNfL<\/jats:styled-content> after adjusting for established predictors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In conclusion, among patients admitted within 24 h of <jats:styled-content style=\"fixed-case\">AIS<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">TIA<\/jats:styled-content> onset, admission <jats:styled-content style=\"fixed-case\">sNfL<\/jats:styled-content> levels were associated with clinical severity on admission and <jats:styled-content style=\"fixed-case\">TIA<\/jats:styled-content> diagnosis, but not with infarct size on <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DWI<\/jats:styled-content> acquired on admission or functional outcome at 3 months.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13554","type":"journal-article","created":{"date-parts":[[2017,12,27]],"date-time":"2017-12-27T14:14:11Z","timestamp":1514384051000},"page":"562-568","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":100,"title":["Serum neurofilament light chain in patients with acute cerebrovascular events"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0342-9780","authenticated-orcid":false,"given":"G. M.","family":"De Marchis","sequence":"first","affiliation":[{"name":"Department of Neurology and Stroke Center University Hospital Basel, University of Basel Basel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Katan","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Zurich Zurich"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Barro","sequence":"additional","affiliation":[{"name":"Department of Neurology and Stroke Center University Hospital Basel, University of Basel Basel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Fladt","sequence":"additional","affiliation":[{"name":"Department of Neurology and Stroke Center University Hospital Basel, University of Basel Basel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Traenka","sequence":"additional","affiliation":[{"name":"Department of Neurology and Stroke Center University Hospital Basel, University of Basel Basel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. J.","family":"Seiffge","sequence":"additional","affiliation":[{"name":"Department of Neurology and Stroke Center University Hospital Basel, University of Basel Basel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Hert","sequence":"additional","affiliation":[{"name":"Department of Neurology and Stroke Center University Hospital Basel, University of Basel Basel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Gensicke","sequence":"additional","affiliation":[{"name":"Department of Neurology and Stroke Center University Hospital Basel, University of Basel Basel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Disanto","sequence":"additional","affiliation":[{"name":"Department of Neurology Neurocenter of Southern Switzerland Lugano"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Sutter","sequence":"additional","affiliation":[{"name":"Department of Neurology and Stroke Center University Hospital Basel, University of Basel Basel"},{"name":"Department of Intensive Care Medicine University Hospital Basel, University of Basel Basel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Peters","sequence":"additional","affiliation":[{"name":"Department of Neurology and Stroke Center University Hospital Basel, University of Basel Basel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Sarikaya","sequence":"additional","affiliation":[{"name":"Department of Neurology Inselspital Bern"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Goeggel\u2010Simonetti","sequence":"additional","affiliation":[{"name":"Department of Neurology Inselspital Bern"},{"name":"Department of Pediatrics San Giovanni Hospital Bellinzona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"El\u2010Koussy","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology Inselspital Bern"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Engelter","sequence":"additional","affiliation":[{"name":"Department of Neurology and Stroke Center University Hospital Basel, University of Basel Basel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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