{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T16:15:35Z","timestamp":1770221735018,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,1,18]],"date-time":"2018-01-18T00:00:00Z","timestamp":1516233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81701171"],"award-info":[{"award-number":["81701171"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Non\u2010alcoholic fatty liver disease (<jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>) is closely correlated to visceral obesity, dyslipidaemia, insulin resistance and type 2 diabetes mellitus. We sought to assess the association between a specific stroke subgroup, brainstem infarctions (<jats:styled-content style=\"fixed-case\">BSI<\/jats:styled-content>s) and <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>. Furthermore, we evaluated whether <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content> is an independent risk factor in patients with <jats:styled-content style=\"fixed-case\">BSI<\/jats:styled-content>s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Non\u2010alcoholic fatty liver disease was assessed in 306 patients with radiologically confirmed <jats:styled-content style=\"fixed-case\">BSI<\/jats:styled-content>s via liver ultrasound. Differences between patients with and without <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content> were compared. Data associated with stroke severity and progression after admission were collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Non\u2010alcoholic fatty liver disease was found in 130 (42.5%) patients with acute <jats:styled-content style=\"fixed-case\">BSI<\/jats:styled-content>s; 58 (19.0%) had National Institutes of Health Stroke Scale scores &gt;7 and 57 (18.6%) had progression after admission. Initial National Institutes of Health Stroke Scale scores, incidence of progression and stroke severity, and modified Rankin Scale scores at discharge were significantly higher in patients with <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content> than in those without <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content> was associated with stroke severity [Cox regression: hazard ratio (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>), 2.243; 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>), 1.254\u20134.013, <jats:italic>P<\/jats:italic> &lt; 0.01]. This risk remained statistically significant after controlling for age, gender, diabetes mellitus and C\u2010reactive protein (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>, 2.327; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.252\u20134.324, <jats:italic>P<\/jats:italic> &lt; 0.01). In addition, <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content> was associated with progression (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>, 2.155; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.201\u20133.865, <jats:italic>P<\/jats:italic> &lt; 0.05) and remained significant after controlling for age, gender, diabetes mellitus, fibrinogen and C\u2010reactive protein (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>, 2.378; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.260\u20134.486, <jats:italic>P<\/jats:italic> &lt; 0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results suggest that <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content> is a potential risk factor when evaluating the severity and progression of acute <jats:styled-content style=\"fixed-case\">BSI<\/jats:styled-content>s. This relationship is independent of classic risk factors and metabolic syndrome features.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13556","type":"journal-article","created":{"date-parts":[[2017,12,27]],"date-time":"2017-12-27T14:14:02Z","timestamp":1514384042000},"page":"577","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Non\u2010alcoholic fatty liver disease is associated with stroke severity and progression of brainstem infarctions"],"prefix":"10.1111","volume":"25","author":[{"given":"H.","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurology The Third Affiliated Hospital of Sun Yat\u2010Sen University Guangzhou"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Hu","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Bioengineering Institute (Guangzhou Sugarcane Industry Research Institute) 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