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In contrast, epidemiological studies are rare in Asia where the <jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content> subtypes differ from those in Western countries. This study was undertaken to clarify the incidence of <jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">FS<\/jats:styled-content> in a local area in Japan as well as their seasonal trends.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Seventy\u2010one <jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content> and 37 <jats:styled-content style=\"fixed-case\">FS<\/jats:styled-content> patients were recorded from 2006 to 2015 in an area of approximately 1.5 million inhabitants in Japan. The incidence, seasonal trends and clinical features of <jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">FS<\/jats:styled-content> were examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The incidence rate of <jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content> was 0.42 cases per 100\u00a0000 person\u2010years and that of <jats:styled-content style=\"fixed-case\">FS<\/jats:styled-content> was 0.22 cases per 100\u00a0000 person\u2010years. The incidence of <jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content> increased with age and <jats:styled-content style=\"fixed-case\">FS<\/jats:styled-content> affected predominantly patients aged from 45 to 64\u00a0years old. There was some seasonal clustering of acute motor axonal neuropathy (<jats:styled-content style=\"fixed-case\">AMAN<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">FS<\/jats:styled-content> in spring and summer, but it was not significant. <jats:styled-content style=\"fixed-case\">AMAN<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">FS<\/jats:styled-content> patients had a high frequency of preceding infection (<jats:styled-content style=\"fixed-case\">AMAN<\/jats:styled-content>, 68% gastrointestinal infection; <jats:styled-content style=\"fixed-case\">FS<\/jats:styled-content>, 65% upper respiratory infection). Antecedent respiratory infection was significantly associated with <jats:styled-content style=\"fixed-case\">FS<\/jats:styled-content> as an outcome. Serum antibodies to ganglioside <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content>1 were detected in 71% of <jats:styled-content style=\"fixed-case\">AMAN<\/jats:styled-content> patients and antibodies to <jats:styled-content style=\"fixed-case\">GQ<\/jats:styled-content>1b were detected in 81% of <jats:styled-content style=\"fixed-case\">FS<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study offers evidence of a lower incidence of <jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content> and a higher incidence of <jats:styled-content style=\"fixed-case\">FS<\/jats:styled-content> in a local area in Japan than in Western countries.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13569","type":"journal-article","created":{"date-parts":[[2018,1,16]],"date-time":"2018-01-16T16:36:13Z","timestamp":1516120573000},"page":"718-724","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Guillain\u2212Barr\u00e9 syndrome in a local area in Japan, 2006\u20132015: an epidemiological and clinical study of 108 patients"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4158-3030","authenticated-orcid":false,"given":"N.","family":"Matsui","sequence":"first","affiliation":[{"name":"Department of Clinical Neuroscience Graduate School of Biomedical Sciences Tokushima University Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5357-5081","authenticated-orcid":false,"given":"H.","family":"Nodera","sequence":"additional","affiliation":[{"name":"Department of 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