{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T10:57:36Z","timestamp":1778756256059,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T00:00:00Z","timestamp":1522972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Patients with Parkinson's disease (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>) with resting tremor may be affected by a tremor that appears after a varying latency while a posture is maintained, a phenomenon referred to as re\u2010emergent tremor (<jats:styled-content style=\"fixed-case\">RET<\/jats:styled-content>). The aim of the study was to evaluate the occurrence and clinical features of <jats:styled-content style=\"fixed-case\">RET<\/jats:styled-content> in patients with <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> tested off and on treatment, and to compare the effect of dopaminergic treatment on <jats:styled-content style=\"fixed-case\">RET<\/jats:styled-content> with the effect on resting and action tremor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We consecutively enrolled 100 patients with <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>. Patients were clinically evaluated 24\u00a0h after withdrawal of therapy (off\u2010treatment phase) and 60\u00a0min after therapy administration (on\u2010treatment phase). We collected the demographic and clinical data of patients with <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>. The severity of the disease was assessed by means of the Hoehn and Yahr scale and Movement Disorder Society\u2010sponsored revision of the Unified Parkinson's Disease Rating Scale part <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>. We evaluated the latency, severity and body side affected both off and on treatment in patients with <jats:styled-content style=\"fixed-case\">RET<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Re\u2010emergent tremor was present in 24% of the patients with <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> off treatment and in 19% of the patients on treatment. Dopaminergic treatment reduced the clinical severity of <jats:styled-content style=\"fixed-case\">RET<\/jats:styled-content>. Dopaminergic treatment increased the number of patients with unilateral <jats:styled-content style=\"fixed-case\">RET<\/jats:styled-content> and reduced the number of those who had bilateral <jats:styled-content style=\"fixed-case\">RET<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">RET<\/jats:styled-content> and resting tremor responded similarly to dopaminergic treatment, whereas action tremor was less responsive. Patients with <jats:styled-content style=\"fixed-case\">RET<\/jats:styled-content> had milder motor symptoms than patients without <jats:styled-content style=\"fixed-case\">RET<\/jats:styled-content> both off and on treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Dopaminergic treatment modified <jats:styled-content style=\"fixed-case\">RET<\/jats:styled-content> occurrence, severity and body distribution. Dopaminergic depletion plays a role in the pathophysiology of <jats:styled-content style=\"fixed-case\">RET<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13619","type":"journal-article","created":{"date-parts":[[2018,3,7]],"date-time":"2018-03-07T10:46:44Z","timestamp":1520419604000},"page":"799-804","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Re\u2010emergent tremor in Parkinson's disease: the effect of dopaminergic treatment"],"prefix":"10.1111","volume":"25","author":[{"given":"D.","family":"Belvisi","sequence":"first","affiliation":[{"name":"Neuromed Institute Pozzilli Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Conte","sequence":"additional","affiliation":[{"name":"Neuromed Institute Pozzilli Italy"},{"name":"Department of Human Neuroscience Sapienza University of Rome Rome 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