{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:44:35Z","timestamp":1791434675321,"version":"4.3.3"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T00:00:00Z","timestamp":1523836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Cardiovascular events are a major cause of early death in the Huntington's disease (<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>) population. Dysautonomia as well as deterioration of circadian rhythms can be detected early in the disease progression and can have profound effects on cardiac health. The aim of the present study was to determine if patients with <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> and pre\u2010manifest mutation carriers present a higher risk of cardiovascular disease than non\u2010mutation\u2010carrying controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective, cross\u2010sectional, multicentre study of 38 <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> mutation carriers (23 pre\u2010manifest and 15 early\u2010stage patients) compared with 38 age\u2010 and gender\u2010matched healthy controls. Clinical and epidemiological variables, including the main haematological vascular risk factors, were recorded. Ambulatory blood\u2010pressure monitoring and carotid intima\u2013media thickness (<jats:styled-content style=\"fixed-case\">CIMT<\/jats:styled-content>) measurement were performed to assess autonomic function and as target\u2010organ damage markers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Most (63.2%) patients with <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> (86.7% and 47.8%, respectively, of the early\u2010stage and pre\u2010manifest patients) were non\u2010dippers compared with 23.7% of controls (<jats:italic>P<\/jats:italic> = 0.001). <jats:styled-content style=\"fixed-case\">CIMT<\/jats:styled-content> values were in the 75<jats:sup>th<\/jats:sup> percentile in 46.7% and 43.5%, respectively, of the early\u2010stage and pre\u2010manifest patients, whereas none of the controls presented pathological values (<jats:italic>P<\/jats:italic> = 0.001 and <jats:italic>P<\/jats:italic> = 0.006, respectively). Nocturnal non\u2010dipping was significantly associated with <jats:styled-content style=\"fixed-case\">CIMT<\/jats:styled-content> values in patients (<jats:italic>P<\/jats:italic> = 0.002) but not in controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results suggest that higher cardiovascular risks and target\u2010organ damage are present even in pre\u2010manifest patients. Although larger studies are needed to confirm these findings, clinicians should consider these results in the cardiovascular management of patients with <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13630","type":"journal-article","created":{"date-parts":[[2018,3,15]],"date-time":"2018-03-15T12:13:15Z","timestamp":1521115995000},"page":"956-962","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Neurocardiovascular pathology in pre\u2010manifest and early\u2010stage Huntington's disease"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0002-8041","authenticated-orcid":false,"given":"E.","family":"Bellosta Diago","sequence":"first","affiliation":[{"name":"Neurology Department Hospital Cl\u00ednico Universitario Lozano Blesa Zaragoza Spain"},{"name":"Resarch Group of Movement Disorders and Headache (GIIS070) Instituto 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