{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T01:53:11Z","timestamp":1790041991201,"version":"4.0.1"},"reference-count":16,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T00:00:00Z","timestamp":1523836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008894","name":"Stryker","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008894","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008209","name":"University at Buffalo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008209","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2018,9]]},"abstract":"\n Background and purpose<\/jats:title>\n \n Tandem anterior circulation lesions in the setting of acute ischemic stroke (\n AIS<\/jats:styled-content>\n ) are a complex endovascular situation that has not been specifically addressed in trials. We determined the predictors of successful reperfusion and good clinical outcome at 90 days after mechanical thrombectomy (\n MT<\/jats:styled-content>\n ) in patients with\n AIS<\/jats:styled-content>\n with tandem lesions in a pooled collaborative study.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This was a retrospective analysis of consecutive patients presenting to 18 comprehensive stroke centers with\n AIS<\/jats:styled-content>\n due to tandem lesion of the anterior circulation who underwent\n MT<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 395 patients were included. Successful reperfusion (modified thrombolysis in cerebral infarction score 2b\u20133) was achieved in 76.7%. At 90 days, 52.2% achieved a good outcome (modified Rankin Scale score 0\u20132), 13.8% suffered a parenchymal hematoma and 13.2% were dead. Lower National Institutes of Health Stroke Scale score [odds ratio (\n OR<\/jats:styled-content>\n ), 1.26; 95% confidence intervals (\n CI<\/jats:styled-content>\n ), 1.07\u20131.48,\n P<\/jats:italic>\n = 0.004], Alberta Stroke Program Early\n CT<\/jats:styled-content>\n Score \u22657 (\n OR<\/jats:styled-content>\n , 2.00; 95%\n CI<\/jats:styled-content>\n , 1.07\u20133.43,\n P<\/jats:italic>\n = 0.011), intravenous thrombolysis (\n OR<\/jats:styled-content>\n , 1.47; 95%\n CI<\/jats:styled-content>\n , 1.01\u20132.12,\n P<\/jats:italic>\n = 0.042) and stenting of the extracranial carotid lesion (\n OR<\/jats:styled-content>\n , 1.63; 95%\n CI<\/jats:styled-content>\n , 1.04\u20132;53,\n P<\/jats:italic>\n = 0.030) were independently associated with successful reperfusion. Lower age (\n OR<\/jats:styled-content>\n , 1.58; 95%\n CI<\/jats:styled-content>\n , 1.26\u20131.97,\n P<\/jats:italic>\n < 0.001), absence of hypercholesterolemia (\n OR<\/jats:styled-content>\n , 1.77; 95%\n CI<\/jats:styled-content>\n , 1.10\u20132.84,\n P<\/jats:italic>\n = 0.018), lower National Institutes of Health Stroke Scale scores (\n OR<\/jats:styled-content>\n , 2.04; 95%\n CI<\/jats:styled-content>\n , 1.53\u20132.72,\n P<\/jats:italic>\n < 0.001), Alberta Stroke Program Early\n CT<\/jats:styled-content>\n Score \u22657 (\n OR<\/jats:styled-content>\n , 2.75; 95%\n CI<\/jats:styled-content>\n , 1.24\u20136.10,\n P<\/jats:italic>\n = 0.013) and proximal middle cerebral artery occlusion (\n OR<\/jats:styled-content>\n , 1.59; 95%\n CI<\/jats:styled-content>\n , 1.03\u20132.44,\n P<\/jats:italic>\n = 0.035) independently predicted a good 90\u2010day outcome.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Intravenous thrombolysis and emergent stenting of the extracranial carotid lesion were predictors of a successful reperfusion after\n MT<\/jats:styled-content>\n of patients with\n AIS<\/jats:styled-content>\n with tandem lesion of the anterior circulation.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ene.13633","type":"journal-article","created":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T09:39:03Z","timestamp":1521970743000},"page":"1115-1120","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":75,"title":["Impact of intravenous thrombolysis and emergent carotid stenting on reperfusion and clinical outcomes in patients with acute stroke with tandem lesion treated with thrombectomy: a collaborative pooled analysis"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8424-4464","authenticated-orcid":false,"given":"B.","family":"Gory","sequence":"first","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology INSERM U947 University Hospital of Nancy Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1884-2196","authenticated-orcid":false,"given":"D. C.","family":"Haussen","sequence":"additional","affiliation":[{"name":"Department of Neurology Emory University\/Grady Memorial Hospital Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Piotin","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology Rothschild Foundation Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Steglich\u2010Arnholm","sequence":"additional","affiliation":[{"name":"Department of Neurology Rigshospitalet Copenhagen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Holtmannsp\u00f6tter","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Labreuche","sequence":"additional","affiliation":[{"name":"Department of Biostatistics EA2694\u2010Sant\u00e9 Publique: Epid\u00e9miologie et Qualit\u00e9 Des Soins Lille University Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kyheng","sequence":"additional","affiliation":[{"name":"Department of Biostatistics EA2694\u2010Sant\u00e9 Publique: Epid\u00e9miologie et Qualit\u00e9 Des Soins Lille University Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Taschner","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology Medical Center\u2010University of Freiburg Freiburg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Eiden","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology Medical Center\u2010University of Freiburg Freiburg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. G.","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Department of Neurology Emory University\/Grady Memorial Hospital Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Papanagiotou","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology Klinikum Bremen\u2010Mitte\/Bremen\u2010Ost Bremen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Boutchakova","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology Klinikum Bremen\u2010Mitte\/Bremen\u2010Ost Bremen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. H.","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University at Buffalo State University of New York Buffalo NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Lapergue","sequence":"additional","affiliation":[{"name":"Department of Neurology Stroke Center Foch Hospital Suresnes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Dorn","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology University Hospital of Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Cognard","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology University Hospital of Toulouse Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Killer","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology Christian Doppler Clinic Research Institute for Neurointervention Paracelsus Medical University Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Mangiafico","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology Careggi University Hospital Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ribo","sequence":"additional","affiliation":[{"name":"Department of Neurology Hospital Vall D'Hebron Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. N.","family":"Psychogios","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology University Medical Center G\u00f6ttingen G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. M.","family":"Spiotta","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Medical University of South Carolina Charleston SC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A.","family":"Labeyrie","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology Lariboisi\u00e8re Hospital Paris"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Biondi","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology and Endovascular Therapeutic University Hospital of Besan\u00e7on Besan\u00e7on"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Mazighi","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology Rothschild Foundation Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Turjman","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology Hospices Civils de Lyon Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Thrombectomy In TANdem lesions (TITAN) investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00163-X"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(16)30177-6"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.7326\/M16-1536"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-016-4338-y"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.016182"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.018264"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.001972"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)08020-9"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.016456"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.599399"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2016.01.007"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2016.5374"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.012586"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.017320"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60949-0"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.116.016368"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fene.13633","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.13633","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T05:10:20Z","timestamp":1695013820000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.13633"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,16]]},"references-count":16,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1111\/ene.13633"],"URL":"https:\/\/doi.org\/10.1111\/ene.13633","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,16]]},"assertion":[{"value":"2017-10-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-02-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}