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However, the results are not conclusive and new studies are needed to elucidate clinical factors that influence the poor outcome. The aim of this study was to identify the clinical factors (including <jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content> etiology) that influence the poor outcome associated with hyperthermia and <jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content>. We also tried to identify potential mechanisms involved in hyperthermia during <jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective study enrolling patients with non\u2010traumatic <jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content> from a prospective registry. We used logistic regression models to analyze the influence of hyperthermia in relation to different inflammatory and endothelial dysfunction markers, hematoma growth and edema volume in hypertensive and non\u2010hypertensive patients with <jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 887 patients with <jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content> (433 hypertensive, 50 amyloid, 117 by anticoagulants and 287 with other causes). Patients with hypertensive <jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content> showed the highest body temperature (37.5 \u00b1 0.8\u00b0C) as well as the maximum increase in temperature (0.9 \u00b1 0.1\u00b0C) within the first 24 h. Patients with <jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content> of hypertensive etiologic origin, who presented hyperthermia, showed a 5.3\u2010fold higher risk of a poor outcome at 3 months. We found a positive relationship (<jats:italic>r<\/jats:italic> = 0.717, <jats:italic>P<\/jats:italic> &lt; 0.0001) between edema volume and hyperthermia during the first 24 h but only in patients with <jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content> of hypertensive etiologic origin. This relationship seems to be mediated by inflammatory markers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data suggest that hyperthermia, together with inflammation and edema, is associated with poor outcome only in <jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content> of hypertensive etiology.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13677","type":"journal-article","created":{"date-parts":[[2018,5,11]],"date-time":"2018-05-11T23:50:54Z","timestamp":1526082654000},"page":"1161-1168","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Inflammation, edema and poor outcome are associated with hyperthermia in hypertensive intracerebral hemorrhages"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9985-9135","authenticated-orcid":false,"given":"R.","family":"Iglesias\u2010Rey","sequence":"first","affiliation":[{"name":"Clinical 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