{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:33:17Z","timestamp":1783038797793,"version":"3.54.6"},"reference-count":13,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,7,11]],"date-time":"2018-07-11T00:00:00Z","timestamp":1531267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>The clinical course and optimal treatment strategy for asymptomatic extracranial carotid artery aneurysms (<jats:styled-content style=\"fixed-case\">ECAAs<\/jats:styled-content>) are unknown. We report our single\u2010center experience with conservative management of patients with an asymptomatic <jats:styled-content style=\"fixed-case\">ECAA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A search in our hospital records from 1998 to 2013 revealed 20 patients [mean age 52 (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 12.5) years] with 23 <jats:styled-content style=\"fixed-case\">ECAAs<\/jats:styled-content>, defined as a 150% or more fusiform dilation or any saccular dilatation compared with the healthy internal carotid artery. None of the aneurysms were treated and we had no pre\u2010defined follow\u2010up schedule for these patients. The primary study end\u2010point was the yearly rate for ipsilateral ischemic stroke. Secondary end\u2010points were ipsilateral transient ischemic attack, any stroke\u2010related death, other symptoms related to the aneurysm or growth defined as any diameter increase.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">ECAA<\/jats:styled-content> was either fusiform (<jats:italic>n<\/jats:italic> = 6; mean diameter 10.2 mm) or saccular (<jats:italic>n<\/jats:italic> = 17; mean diameter 10.9 mm). Eleven (55%) patients with 13 <jats:styled-content style=\"fixed-case\">ECAAs<\/jats:styled-content> received antithrombotic medication. During follow\u2010up [median 46.5 (range 1\u2013121) months], one patient died due to ipsilateral stroke and the ipsilateral cerebral stroke rate was 1.1 per 100 patient\u2010years (95% confidence interval, 0.01\u20136.3). Three patients had <jats:styled-content style=\"fixed-case\">ECAA<\/jats:styled-content> growth, two of whom were asymptomatic and one was the patient who suffered a stroke.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this retrospective case series of patients with an asymptomatic <jats:styled-content style=\"fixed-case\">ECAA<\/jats:styled-content>, the risk of cerebral infarction is small but not negligible. Conservative management seems justified, in particular in patients without growth. Large prospective registry data are necessary to assess follow\u2010up imaging strategies and the role of antiplatelet therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13720","type":"journal-article","created":{"date-parts":[[2018,6,15]],"date-time":"2018-06-15T01:17:11Z","timestamp":1529025431000},"page":"1285-1289","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Experience of a single center in the conservative approach of 20 consecutive cases of asymptomatic extracranial carotid artery aneurysms"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4766-8289","authenticated-orcid":false,"given":"V. E. C.","family":"Pourier","sequence":"first","affiliation":[{"name":"Department of Vascular Surgery University Medical Center Utrecht Utrecht"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. C.","family":"Welleweerd","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery University Medical Center Utrecht Utrecht"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. J.","family":"Kappelle","sequence":"additional","affiliation":[{"name":"Brain Center Rudolf Magnus Department of Neurology and Neurosurgery University Medical Center Utrecht Utrecht"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. J. E.","family":"Rinkel","sequence":"additional","affiliation":[{"name":"Brain Center Rudolf Magnus Department of Neurology and Neurosurgery University Medical Center Utrecht Utrecht"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. M.","family":"Ruigrok","sequence":"additional","affiliation":[{"name":"Brain Center Rudolf Magnus Department of Neurology and Neurosurgery University Medical Center Utrecht Utrecht"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. B.","family":"van der Worp","sequence":"additional","affiliation":[{"name":"Brain Center Rudolf Magnus Department of Neurology and Neurosurgery University Medical Center Utrecht Utrecht"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. H.","family":"Lo","sequence":"additional","affiliation":[{"name":"Department of Radiology University Medical Center Utrecht Utrecht"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. L.","family":"Bots","sequence":"additional","affiliation":[{"name":"Julius Center for Health Sciences and Primary Care University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. L.","family":"Moll","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery University Medical Center Utrecht Utrecht"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. J.","family":"de Borst","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery University Medical Center Utrecht Utrecht"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2015.05.002"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0117915"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0950-821X(89)80132-X"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(79)90144-2"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2006.10.004"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2000.104101"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0741-5214(84)90079-X"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1926.01130110090008"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2016.03.021"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2014.07.092"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.32.2.418"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.324.7329.71"},{"key":"e_1_2_7_14_1","article-title":"Rationale and design of the extracranial carotid artery aneurysm registry (CAR)","author":"Welleweerd JC","year":"2015","journal-title":"J Cardiovasc Surg (Torino)"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fene.13720","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.13720","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ene.13720","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.13720","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T18:19:23Z","timestamp":1693333163000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.13720"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,11]]},"references-count":13,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1111\/ene.13720"],"URL":"https:\/\/doi.org\/10.1111\/ene.13720","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,11]]},"assertion":[{"value":"2018-01-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}