{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T07:39:47Z","timestamp":1778830787148,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,8,3]],"date-time":"2018-08-03T00:00:00Z","timestamp":1533254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>External counterpulsation improves cerebral perfusion velocity in acute stroke and may stimulate collateral artery growth. However, whether (non\u2010acute) at\u2010risk patients with high\u2010grade carotid artery disease may benefit from counterpulsation needs to be validated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010eight patients (71 \u00b1 6.5 years, five women) with asymptomatic unilateral chronic severe internal carotid artery stenosis (&gt;70%) or occlusion were randomized to receive 20 min active counterpulsation followed by sham treatment or vice versa. Cerebral blood flow velocity (<jats:styled-content style=\"fixed-case\">CBFV<\/jats:styled-content>) (measured bilaterally by transcranial middle cerebral artery Doppler), tissue oxygenation index (<jats:styled-content style=\"fixed-case\">TOI<\/jats:styled-content>) (measured over the bilateral prefrontal cortex by near\u2010infrared spectroscopy) and cerebral hemodynamic parameters, such as relative pulse slope index (<jats:styled-content style=\"fixed-case\">RPSI<\/jats:styled-content>), were monitored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ipsilateral mean <jats:styled-content style=\"fixed-case\">CBFV<\/jats:styled-content> (\u0394<jats:italic>V<\/jats:italic><jats:sub>mean<\/jats:sub> +3.5 \u00b1 1.2 cm\/s) and tissue oxygenation (\u0394<jats:styled-content style=\"fixed-case\">TOI<\/jats:styled-content> +2.86 \u00b1 0.8) increased significantly during active counterpulsation compared to baseline, whilst the sham had little effect (\u0394<jats:italic>V<\/jats:italic><jats:sub>mean<\/jats:sub> +1.13 \u00b1 1.1 cm\/s; \u0394<jats:styled-content style=\"fixed-case\">TOI<\/jats:styled-content> +1.25 \u00b1 0.65). On contralateral sides, neither counterpulsation nor sham control had any effect on either parameter. During counterpulsation, early dynamic changes in \u0394<jats:styled-content style=\"fixed-case\">RPSI<\/jats:styled-content> of the ipsilateral <jats:styled-content style=\"fixed-case\">CBFV<\/jats:styled-content> signal predicted improved tissue oxygenation during counterpulsation (odds ratio 1.179, 95% confidence interval 1.01\u20131.51), whilst baseline cerebrovascular reactivity to hypercapnia failed to show an association.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients with high\u2010grade carotid disease, ipsilateral cerebral oxygenation and blood flow velocity are increased by counterpulsation. This is a necessary condition for the stimulation of regenerative collateral artery growth and thus a therapeutic concept for the prevention of cerebral ischaemia. This study provides a rationale for further clinical investigations on the long\u2010term effects of counterpulsation on cerebral hemodynamics and collateral growth.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13725","type":"journal-article","created":{"date-parts":[[2018,6,20]],"date-time":"2018-06-20T20:40:32Z","timestamp":1529527232000},"page":"1326-1332","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Short\u2010term external counterpulsation augments cerebral blood flow and tissue oxygenation in chronic cerebrovascular occlusive disease"],"prefix":"10.1111","volume":"25","author":[{"given":"E. E.","family":"Buschmann","sequence":"first","affiliation":[{"name":"Department for Cardiology Center of Internal Medicine Medical University Graz Graz Austria"},{"name":"Brandenburg School of Medicine Center for Internal Medicine I Department for Angiology Brandenburg an der Havel Germany"},{"name":"Department of Cardiology Charit\u00e9 Universitaetsmedizin Berlin, Campus Virchow Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Hillmeister","sequence":"additional","affiliation":[{"name":"Brandenburg School of Medicine Center for Internal Medicine I Department for Angiology Brandenburg an der Havel Germany"},{"name":"Department of Cardiology Charit\u00e9 Universitaetsmedizin Berlin, Campus Virchow Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Bondke Persson","sequence":"additional","affiliation":[{"name":"Institute of Vegetative Physiology Charit\u00e9 Universitaetsmedizin Berlin Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. S.","family":"Liebeskind","sequence":"additional","affiliation":[{"name":"Neurovascular Imaging Research Core and UCLA Stroke Center Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Schlich","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Freiburg Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Kamenzky","sequence":"additional","affiliation":[{"name":"Department of Cardiology Charit\u00e9 Universitaetsmedizin Berlin, Campus Virchow Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Busjahn","sequence":"additional","affiliation":[{"name":"HealthTwiSt GmbH Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. R.","family":"Buschmann","sequence":"additional","affiliation":[{"name":"Brandenburg School of Medicine Center for Internal Medicine I Department for Angiology Brandenburg an der Havel Germany"},{"name":"Department of Cardiology Charit\u00e9 Universitaetsmedizin Berlin, Campus Virchow Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4970-2110","authenticated-orcid":false,"given":"P.","family":"Bramlage","sequence":"additional","affiliation":[{"name":"Brandenburg School of Medicine Center for Internal Medicine I Department for Angiology Brandenburg an der Havel Germany"},{"name":"Institute f\u00fcr Pharmakologie und Pr\u00e4ventive Medizin Cloppenburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Hetzel","sequence":"additional","affiliation":[{"name":"Schwarzwaldklinik Neurologie Bad Krozingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Reinhard","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Freiburg Freiburg Germany"},{"name":"Department of Neurology and Clinical Neurophysiology Medical Center Esslingen Academic Teaching Hospital of the University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,8,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.005645"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22354"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2008.165"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.045351"},{"key":"e_1_2_7_6_1","first-page":"37","article-title":"Enhanced external counterpulsation in unrevascularizable patients","volume":"3","author":"Barsness GW","year":"2001","journal-title":"Curr Interv Cardiol Rep"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00428-5"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2009.02192.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.512418"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000319891"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.112.659144"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2013.09.023"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2011.01515.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.30.2.398"},{"key":"e_1_2_7_15_1","author":"R Core Team. R","year":"2018","journal-title":"A language and environment for statistical computing."},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0404880101"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fene.13725","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.13725","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T12:46:41Z","timestamp":1694868401000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.13725"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,3]]},"references-count":15,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.1111\/ene.13725"],"URL":"https:\/\/doi.org\/10.1111\/ene.13725","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,3]]},"assertion":[{"value":"2018-01-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}