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Literature was reviewed to assess study design, risk of bias, inconsistency, imprecision, indirectness and effect size. Critical outcomes were sensitivity, specificity, accuracy, positive\/negative predictive value, area under the receiver operating characteristic curve, and positive\/negative likelihood ratio of <jats:styled-content style=\"fixed-case\">FDG<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content> in detecting the target conditions. Using the Delphi method, an expert panel voted for\/against the use of <jats:styled-content style=\"fixed-case\">FDG<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content> based on published evidence and expert opinion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 1435 papers, 58 papers provided proper quantitative assessment of test performance. The panel agreed on recommending <jats:styled-content style=\"fixed-case\">FDG<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content> for 14 questions: diagnosing mild cognitive impairment due to Alzheimer's disease (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>), frontotemporal lobar degeneration (<jats:styled-content style=\"fixed-case\">FTLD<\/jats:styled-content>) or dementia with Lewy bodies (<jats:styled-content style=\"fixed-case\">DLB<\/jats:styled-content>); diagnosing atypical <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> and pseudo\u2010dementia; differentiating between <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">DLB<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> FTLD<\/jats:styled-content> or vascular dementia, between <jats:styled-content style=\"fixed-case\">DLB<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">FTLD<\/jats:styled-content>, and between Parkinson's disease and progressive supranuclear palsy; suggesting underlying pathophysiology in corticobasal degeneration and progressive primary aphasia, and cortical dysfunction in Parkinson's disease; using semi\u2010automated assessment to assist visual reading. Panellists did not support <jats:styled-content style=\"fixed-case\">FDG<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content> use for pre\u2010clinical stages of neurodegenerative disorders, for amyotrophic lateral sclerosis and Huntington disease diagnoses, and for amyotrophic lateral sclerosis or Huntington\u2010disease\u2010related cognitive decline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Despite limited formal evidence, panellists deemed <jats:styled-content style=\"fixed-case\">FDG<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content> useful in the early and differential diagnosis of the main neurodegenerative disorders, and semi\u2010automated assessment helpful to assist visual reading. 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