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When ag<jats:styled-content style=\"fixed-case\">PPA<\/jats:styled-content> includes <jats:styled-content style=\"fixed-case\">AOS<\/jats:styled-content>, a tauopathy is the likely underlying pathology. Recently, [18F]<jats:styled-content style=\"fixed-case\">AV<\/jats:styled-content>\u20101451 was developed for the <jats:italic>in\u2010vivo<\/jats:italic> assessment of tau. In this study, we compared patterns of tau tracer uptake in patients with ag<jats:styled-content style=\"fixed-case\">PPA<\/jats:styled-content> with and without AOS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nine patients with ag<jats:styled-content style=\"fixed-case\">PPA<\/jats:styled-content> (four without <jats:styled-content style=\"fixed-case\">AOS<\/jats:styled-content>) underwent tau positron emission tomography imaging with [18F]<jats:styled-content style=\"fixed-case\">AV<\/jats:styled-content>\u20101451. Uptake of [18F]<jats:styled-content style=\"fixed-case\">AV<\/jats:styled-content>\u20101451 was assessed as cortical to cerebellar crus ratio (standard uptake value ratio) in cortical regions of interest measured using the <jats:styled-content style=\"fixed-case\">MCALT<\/jats:styled-content> atlas and compared voxel\u2010wise in <jats:styled-content style=\"fixed-case\">SPM<\/jats:styled-content>12. Each patient was age\u2010 and sex\u2010matched to three controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The ag<jats:styled-content style=\"fixed-case\">PPA<\/jats:styled-content> without <jats:styled-content style=\"fixed-case\">AOS<\/jats:styled-content> showed uptake in the left frontal and temporal lobes, whereas ag<jats:styled-content style=\"fixed-case\">PPA<\/jats:styled-content> with <jats:styled-content style=\"fixed-case\">AOS<\/jats:styled-content> showed uptake in the bilateral supplementary motor areas, frontal lobes, precuneus and precentral gyrus relative to controls. The left precentral gyrus had uptake in ag<jats:styled-content style=\"fixed-case\">PPA<\/jats:styled-content> with <jats:styled-content style=\"fixed-case\">AOS<\/jats:styled-content> relative to those without <jats:styled-content style=\"fixed-case\">AOS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This cross\u2010sectional study suggests that [18F]<jats:styled-content style=\"fixed-case\">AV<\/jats:styled-content>\u20101451 uptake in the precentral gyrus is implicated in <jats:styled-content style=\"fixed-case\">AOS<\/jats:styled-content> in ag<jats:styled-content style=\"fixed-case\">PPA<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13733","type":"journal-article","created":{"date-parts":[[2018,6,23]],"date-time":"2018-06-23T11:39:37Z","timestamp":1529753977000},"page":"1352-1357","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Tau uptake in agrammatic primary progressive aphasia with and without apraxia of speech"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9519-1302","authenticated-orcid":false,"given":"R. 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