{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T14:04:50Z","timestamp":1772805890647,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,8,16]],"date-time":"2018-08-16T00:00:00Z","timestamp":1534377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Few recent data are available concerning idiopathic optic neuritis (<jats:styled-content style=\"fixed-case\">ON<\/jats:styled-content>). We aimed to describe a large cohort of patients with idiopathic <jats:styled-content style=\"fixed-case\">ON<\/jats:styled-content>. We compared this cohort with patients with <jats:styled-content style=\"fixed-case\">ON<\/jats:styled-content> related to myelin oligodendrocyte glycoprotein (<jats:styled-content style=\"fixed-case\">MOG<\/jats:styled-content>) or <jats:styled-content style=\"fixed-case\">ON<\/jats:styled-content> related to aquaporin\u20104 (<jats:styled-content style=\"fixed-case\">AQP<\/jats:styled-content>4) antibodies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a monocentric retrospective observational study. Inclusion criteria for idiopathic <jats:styled-content style=\"fixed-case\">ON<\/jats:styled-content> were as follows: age \u2265 16 years, follow\u2010up of at least 2 years, negative for antibodies against <jats:styled-content style=\"fixed-case\">MOG<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">AQP<\/jats:styled-content>4 immunoglobulin G, and no magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) lesions suggestive of demyelination (two brain <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> scans, one at baseline and one during follow\u2010up, and one spinal cord <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> scan).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 23 patients with idiopathic <jats:styled-content style=\"fixed-case\">ON<\/jats:styled-content> (female, 82.6%; median age, 36 years; median follow\u2010up time, 41.4 months), 56.5% had recurrent <jats:styled-content style=\"fixed-case\">ON<\/jats:styled-content> (median time to a second <jats:styled-content style=\"fixed-case\">ON<\/jats:styled-content> episode, 6 months). The final visual acuity in this group (median, 0; mean, 0.43; range, 0\u20133) was similar to that in the <jats:styled-content style=\"fixed-case\">AQP<\/jats:styled-content>4 group (<jats:italic>n<\/jats:italic> = 18; <jats:italic>P<\/jats:italic>\u2010value after Bonferroni correction = 0.936) but worse than that in the <jats:styled-content style=\"fixed-case\">MOG<\/jats:styled-content> group (<jats:italic>n<\/jats:italic> = 25; <jats:italic>P<\/jats:italic>\u2010value after Bonferroni correction = 0.019). At the last evaluation, visual acuity levels were \u22640.5 and &lt;0.2, respectively, in 36.8% and 21% of the idiopathic <jats:styled-content style=\"fixed-case\">ON<\/jats:styled-content> group, 58.3% and 26.7% of the <jats:styled-content style=\"fixed-case\">AQP<\/jats:styled-content>4 group, and 0% and 0% of the <jats:styled-content style=\"fixed-case\">MOG<\/jats:styled-content> group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The recovery of visual acuity among patients with idiopathic <jats:styled-content style=\"fixed-case\">ON<\/jats:styled-content> was poor, similar to that observed in the <jats:styled-content style=\"fixed-case\">AQP<\/jats:styled-content>4 group.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13753","type":"journal-article","created":{"date-parts":[[2018,7,13]],"date-time":"2018-07-13T15:33:29Z","timestamp":1531496009000},"page":"1378-1383","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Acute idiopathic optic neuritis: not always benign"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6291-8771","authenticated-orcid":false,"given":"R.","family":"Deschamps","sequence":"first","affiliation":[{"name":"Department of Neurology Fondation Ophtalmologique Adolphe de Rothschild Paris"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Gueguen","sequence":"additional","affiliation":[{"name":"Department of Neurology Fondation Ophtalmologique Adolphe de Rothschild Paris"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Lecler","sequence":"additional","affiliation":[{"name":"Department of Radiology Fondation Ophtalmologique Adolphe de Rothschild Paris"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Lecouturier","sequence":"additional","affiliation":[{"name":"Department of Neurology Fondation Ophtalmologique Adolphe de Rothschild Paris"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Lamirel","sequence":"additional","affiliation":[{"name":"Department of Neuro\u2010Ophthalmolology Fondation Ophtalmologique Adolphe de Rothschild Paris"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Bensa","sequence":"additional","affiliation":[{"name":"Department of Neurology Fondation Ophtalmologique Adolphe de Rothschild 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