{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:32:23Z","timestamp":1790037143678,"version":"4.0.1"},"reference-count":57,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T00:00:00Z","timestamp":1537488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KFO 219"],"award-info":[{"award-number":["KFO 219"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2019,2]]},"abstract":"Background and purpose<\/jats:title>Subthalamic nucleus (STN) deep brain stimulation (DBS<\/jats:styled-content>) improves quality of life (QoL) and motor and non\u2010motor symptoms in advanced Parkinson's disease (PD<\/jats:styled-content>). However, its effect on alexithymia and its relationship to other neuropsychiatric symptoms and QoL in PD<\/jats:styled-content> is unclear.<\/jats:p><\/jats:sec>Methods<\/jats:title>In this prospective, observational study of 39 patients with PD<\/jats:styled-content> undergoing STN<\/jats:styled-content>\u2010DBS<\/jats:styled-content>, we examined the Parkinson's Disease Questionnaire\u20108 (PDQ<\/jats:styled-content>\u20108), 20\u2010item Toronto Alexithymia Scale (TAS<\/jats:styled-content>\u201020), Hospital Anxiety and Depression Scale (HADS<\/jats:styled-content>), Self\u2010Report Manic Inventory (SRMI<\/jats:styled-content>), Apathy Evaluation Scale (AES<\/jats:styled-content>), Unified Parkinson's Disease Rating Scale (UPDRS) activities of daily living, UPDRS motor examination and UPDRS complications (UPDRS<\/jats:styled-content>\u2010II<\/jats:styled-content>\/\u2010III<\/jats:styled-content>\/\u2010IV<\/jats:styled-content>) and levodopa\u2010equivalent daily dose (LEDD<\/jats:styled-content>) pre\u2010operatively and at 5\u2010month follow\u2010up. Outcome changes were tested with Wilcoxon signed\u2010rank or paired t<\/jats:italic>\u2010test when parametric tests were applicable and corrected for multiple comparisons. The relationship between outcome changes was explored with bivariate correlations. Additionally, partial correlations between PDQ<\/jats:styled-content>\u20108 and TAS<\/jats:styled-content>\u201020 were computed controlling for HADS<\/jats:styled-content>, SRMI<\/jats:styled-content> and AES<\/jats:styled-content> change scores. Predictor analyses for PDQ<\/jats:styled-content>\u20108 improvement were calculated for all baseline parameters.<\/jats:p><\/jats:sec>Results<\/jats:title>The baseline prevalence of alexithymia was 17.9%. We observed significant beneficial effects of STN<\/jats:styled-content>\u2010DBS<\/jats:styled-content> on PDQ<\/jats:styled-content>\u20108, TAS<\/jats:styled-content>\u201020, HADS<\/jats:styled-content>, UPDRS<\/jats:styled-content>\u2010II<\/jats:styled-content>, \u2010III<\/jats:styled-content> and \u2010IV<\/jats:styled-content> scores and significant LEDD<\/jats:styled-content> reduction. The correlation between TAS<\/jats:styled-content>\u201020 and PDQ<\/jats:styled-content>\u20108 improvements remained significant after controlling for all other aforementioned outcomes. Predictor analyses for PDQ<\/jats:styled-content>\u20108 improvement were significant for PDQ<\/jats:styled-content>\u20108 and TAS<\/jats:styled-content>\u201020.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>This is the first report of beneficial effects of STN<\/jats:styled-content>\u2010DBS<\/jats:styled-content> on alexithymia. Alexithymia was significantly associated with QoL outcome independent of anxiety, depression, mania and apathy. Our study highlights the importance of alexithymia for holistic assessments of DBS<\/jats:styled-content> outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13773","type":"journal-article","created":{"date-parts":[[2018,8,14]],"date-time":"2018-08-14T22:05:06Z","timestamp":1534284306000},"page":"222","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Beneficial effects of bilateral subthalamic stimulation on alexithymia in Parkinson's disease"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8849-4233","authenticated-orcid":false,"given":"H. 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