{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:46:32Z","timestamp":1790419592415,"version":"4.1.0"},"reference-count":55,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,9,14]],"date-time":"2018-09-14T00:00:00Z","timestamp":1536883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:p>Females with myasthenia gravis (<jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content>) worry about their disease having negative consequences for their children. Autoimmune disease mechanisms, treatment and heredity could all have an impact on the child. This is a subject review where Web of Science was searched for relevant keywords and combinations. Controlled and prospective studies were included, and also results from selected and unselected patient cohorts, guidelines, consensus papers and reviews. Neonatal <jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content> with temporary muscle weakness occurs in 10% of newborn babies where the mother has <jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content>, due to transplacental transfer of antibodies against acetylcholine receptor (<jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>hR), muscle\u2010specific kinase (Mu<jats:styled-content style=\"fixed-case\">SK<\/jats:styled-content>) or lipoprotein receptor\u2010related protein 4 (<jats:styled-content style=\"fixed-case\">LRP<\/jats:styled-content>4). Arthrogryposis and fetal <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>hR inactivation syndrome with contractures and permanent myopathy are rare events caused by mother's antibodies against fetal type <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>hR. The <jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content> drugs pyridostigmine, prednisolone and azathioprine are regarded as safe during pregnancy and breastfeeding. Methotrexate, mycophenolate mofetil and cyclophosphamide are teratogenic. Mother's <jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content> implies at least a 10\u2010fold increased risk for <jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content> and other autoimmune diseases in the child. MG females should receive specific information about pregnancy and giving birth. First\u2010line <jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content> treatments should usually be continued during pregnancy. Intravenous immunoglobulin and plasma exchange represent safe treatments for exacerbations. Neonatal <jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content> risk means that <jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content> women should give birth at hospitals experienced in neonatal intensive care. Neonatal <jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content> needs supportive care, rarely also acetylcholine esterase inhibition or intravenous immunoglobulin. Women with <jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content> should be supported in their wish to have children.<\/jats:p>","DOI":"10.1111\/ene.13788","type":"journal-article","created":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T16:33:50Z","timestamp":1534955630000},"page":"1402-1409","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Maternal myasthenia gravis represents a risk for the child through autoantibody transfer, immunosuppressive therapy and genetic influence"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6522-5102","authenticated-orcid":false,"given":"N. 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