{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:51:07Z","timestamp":1790761867246,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T00:00:00Z","timestamp":1537747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>An engineered glove measuring finger motor performance previously showed ability to discriminate early\u2010stage multiple sclerosis (<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>) patients from healthy controls (<jats:styled-content style=\"fixed-case\">HCs<\/jats:styled-content>). Radiologically isolated syndrome (<jats:styled-content style=\"fixed-case\">RIS<\/jats:styled-content>) classifies asymptomatic subjects with brain magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) abnormalities suggestive of multiple sclerosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventeen asymptomatic subjects with <jats:styled-content style=\"fixed-case\">RIS<\/jats:styled-content> and 17 <jats:styled-content style=\"fixed-case\">HCs<\/jats:styled-content> were assessed. They performed finger\u2010to\u2010thumb opposition sequences at their maximal velocity, metronome\u2010paced bimanual movements and conventional and diffusion tensor <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Subjects with <jats:styled-content style=\"fixed-case\">RIS<\/jats:styled-content> showed lower (<jats:italic>P<\/jats:italic> = 0.005) maximal velocity and higher (<jats:italic>P<\/jats:italic> = 0.006) bimanual coordination impairment than <jats:styled-content style=\"fixed-case\">HCs<\/jats:styled-content>. In <jats:styled-content style=\"fixed-case\">RIS<\/jats:styled-content>, bimanual coordination correlated with T2\u2010lesion volume, fractional anisotropy and radial diffusivity in the white matter.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings point out the relevance of fine hand measures as a robust marker of subclinical disability.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13789","type":"journal-article","created":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T16:34:14Z","timestamp":1534955654000},"page":"162-167","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Subclinical motor impairment assessed with an engineered glove correlates with magnetic resonance imaging tissue damage in radiologically isolated syndrome"],"prefix":"10.1111","volume":"26","author":[{"given":"L.","family":"Bonzano","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health University of Genoa Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Bove","sequence":"additional","affiliation":[{"name":"Section of Human Physiology Department of Experimental Medicine University of Genoa Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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