{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T08:27:35Z","timestamp":1772180855550,"version":"3.50.1"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,10,15]],"date-time":"2018-10-15T00:00:00Z","timestamp":1539561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>The aim of this study was to analyse the clinical and prognostic features of myelin oligodendrocyte glycoprotein (<jats:styled-content style=\"fixed-case\">MOG<\/jats:styled-content>) antibody\u2010associated demyelination with different onset phenotypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 52 <jats:styled-content style=\"fixed-case\">MOG<\/jats:styled-content>\u2010IgG\u2010seropositive patients were divided into four groups: (i) optic neuritis (<jats:styled-content style=\"fixed-case\">ON<\/jats:styled-content>) at onset (<jats:styled-content style=\"fixed-case\">MOG<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ON<\/jats:styled-content><jats:sup>+<\/jats:sup>, <jats:italic>n<\/jats:italic>\u00a0=\u00a023), (ii) transverse myelitis (<jats:styled-content style=\"fixed-case\">TM<\/jats:styled-content>) at onset (<jats:styled-content style=\"fixed-case\">MOG<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">TM<\/jats:styled-content><jats:sup>+<\/jats:sup>, <jats:italic>n<\/jats:italic>\u00a0=\u00a012), (iii) pure brain symptoms at onset (<jats:styled-content style=\"fixed-case\">MOG<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ON<\/jats:styled-content><jats:sup>\u2212<\/jats:sup>\u2010<jats:styled-content style=\"fixed-case\">TM<\/jats:styled-content><jats:sup>\u2212<\/jats:sup>, <jats:italic>n<\/jats:italic>\u00a0=\u00a014) and (iv) both <jats:styled-content style=\"fixed-case\">ON<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">TM<\/jats:styled-content> at onset (<jats:italic>n<\/jats:italic>\u00a0=\u00a03). This final group was not included in further analyses. Data were collected through medical records and regular follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median age at presentation was 24 (range, 3\u201363)\u00a0years in the whole cohort (50% female). <jats:styled-content style=\"fixed-case\">MOG<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ON<\/jats:styled-content><jats:sup>\u2212<\/jats:sup>\u2010<jats:styled-content style=\"fixed-case\">TM<\/jats:styled-content><jats:sup>\u2212<\/jats:sup> patients had the youngest age of onset across the three groups. Patients with <jats:styled-content style=\"fixed-case\">MOG<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">TM<\/jats:styled-content><jats:sup>+<\/jats:sup> tended to relapse more frequently and had a longer interval to first relapse than was observed in <jats:styled-content style=\"fixed-case\">MOG<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ON<\/jats:styled-content><jats:sup>+<\/jats:sup> and <jats:styled-content style=\"fixed-case\">MOG<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ON<\/jats:styled-content><jats:sup>\u2212<\/jats:sup>\u2010<jats:styled-content style=\"fixed-case\">TM<\/jats:styled-content><jats:sup>\u2212<\/jats:sup> patients. High <jats:styled-content style=\"fixed-case\">MOG<\/jats:styled-content>\u2010IgG titres were associated with increased cerebrospinal fluid leukocytes. The likelihood of harbouring transient, low <jats:styled-content style=\"fixed-case\">MOG<\/jats:styled-content>\u2010IgG titres was higher in the <jats:styled-content style=\"fixed-case\">MOG<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">TM<\/jats:styled-content><jats:sup>+<\/jats:sup> group than in the other groups. After a median disease duration of 20\u00a0months, most but not all cases had a favourable outcome, with 8% developing severe visual deficit, 2% becoming wheelchair\u2010dependent and 6% developing cognitive impairment. The onset phenotype appeared to be an important predictor of disability type. Having high <jats:styled-content style=\"fixed-case\">MOG<\/jats:styled-content>\u2010IgG titres (odds ratio, 0.168, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.027) or female gender (odds ratio, 0.270, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.067) was associated with a lower likelihood of complete recovery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Onset phenotype may influence long\u2010term presentation, <jats:styled-content style=\"fixed-case\">MOG<\/jats:styled-content>\u2010IgG status as well as outcome. Further large and prospective studies are needed to better clarify the clinical implications of the first demyelinating event.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13791","type":"journal-article","created":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T05:04:16Z","timestamp":1535605456000},"page":"175-183","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Myelin oligodendrocyte glycoprotein antibody\u2010associated demyelination: comparison between onset phenotypes"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8810-0943","authenticated-orcid":false,"given":"Y.","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Neurology The Third Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The Third Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Yang","sequence":"additional","affiliation":[{"name":"Zhongshan Ophthalmic Center Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology The Third Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Neurology The Third Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Neurology The Third Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. G.","family":"Kermode","sequence":"additional","affiliation":[{"name":"Department of Neurology The Third Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"},{"name":"Centre for Neuromuscular and Neurological Disorders University of Western Australia Perth WA Australia"},{"name":"Department of Neurology Sir Charles Gairdner Hospital Queen Elizabeth II Medical Centre Perth WA Australia"},{"name":"Institute of Immunology and Infectious Diseases Murdoch University Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Neurology The Third Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004312"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000163"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2017-315998"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx276"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2017-316880"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-016-0718-0"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000005560"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2017.01.007"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2017.4601"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-018-1144-2"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fene.13791","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.13791","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ene.13791","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.13791","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T09:45:44Z","timestamp":1694166344000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.13791"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,15]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1111\/ene.13791"],"URL":"https:\/\/doi.org\/10.1111\/ene.13791","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,15]]},"assertion":[{"value":"2018-05-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}