{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T15:42:58Z","timestamp":1788190978654,"version":"build-2803163510"},"reference-count":6,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,9,30]],"date-time":"2018-09-30T00:00:00Z","timestamp":1538265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>In patients with cervical dystonia, abobotulinumtoxinA solution for injection (<jats:styled-content style=\"fixed-case\">ASI<\/jats:styled-content>) has been shown to be similarly effective to freeze\u2010dried abobotulinumtoxinA in reducing Toronto Western Spasmodic Torticollis Rating Scale (<jats:styled-content style=\"fixed-case\">TWSTRS<\/jats:styled-content>) total scores. In this secondary analysis, quality of life data as evaluated with the Cervical Dystonia Impact Profile (<jats:styled-content style=\"fixed-case\">CDIP<\/jats:styled-content>\u201058) are presented.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a double\u2010blind, randomized, active and placebo\u2010controlled study followed by an open\u2010label extension (<jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>01261611). In the double\u2010blind phase, patients were randomized (3:3:1) to one cycle of <jats:styled-content style=\"fixed-case\">ASI<\/jats:styled-content> 500\u00a0U (<jats:italic>n<\/jats:italic>\u00a0=\u00a0156), abobotulinumtoxinA 500\u00a0U (<jats:italic>n<\/jats:italic>\u00a0=\u00a0159) or placebo (<jats:italic>n<\/jats:italic>\u00a0=\u00a054). Following the double\u2010blind phase, all patients received open\u2010label <jats:styled-content style=\"fixed-case\">ASI<\/jats:styled-content> for up to four cycles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">CDIP<\/jats:styled-content>\u201058 total scores were significantly improved at week 4 of the double\u2010blind phase in both the <jats:styled-content style=\"fixed-case\">ASI<\/jats:styled-content> 500\u00a0U and abobotulinumtoxinA 500\u00a0U groups versus placebo [least squares mean change from baseline of \u22129.5 (\u221211.51, \u22127.45) and \u221211.2 (\u221213.2, \u22129.26) vs. \u22120.9 (\u22124.04, 2.14), respectively; both <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001 vs. placebo]. All <jats:styled-content style=\"fixed-case\">CDIP<\/jats:styled-content>\u201058 domains contributed to this improvement and benefits were maintained across open\u2010label treatment. Positive correlations were observed between <jats:styled-content style=\"fixed-case\">CDIP<\/jats:styled-content>\u201058 total score and all three <jats:styled-content style=\"fixed-case\">TWSTRS<\/jats:styled-content> domains (<jats:italic>R<\/jats:italic>\u00a0=\u00a00.42\u20130.62) and for all <jats:styled-content style=\"fixed-case\">CDIP<\/jats:styled-content>\u201058 subscales with the <jats:styled-content style=\"fixed-case\">TWSTRS<\/jats:styled-content> total score and domains (<jats:italic>R<\/jats:italic>\u00a0=\u00a00.23\u20130.60).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Repeat <jats:styled-content style=\"fixed-case\">ASI<\/jats:styled-content> injections are similarly effective to abobotulinumtoxinA in improving patient\u2010reported outcomes of health\u2010related quality of life. Positive correlations were found between <jats:styled-content style=\"fixed-case\">TWSTRS<\/jats:styled-content> total and domain scores and <jats:styled-content style=\"fixed-case\">CDIP<\/jats:styled-content>\u201058 total and domain scores.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13800","type":"journal-article","created":{"date-parts":[[2018,8,31]],"date-time":"2018-08-31T15:09:38Z","timestamp":1535728178000},"page":"943","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Quality of life improvements in patients with cervical dystonia following treatment with a liquid formulation of abobotulinumtoxinA (Dysport<sup>\u00ae<\/sup>)"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2278-0410","authenticated-orcid":false,"given":"M.","family":"Simonetta\u2010Moreau","sequence":"first","affiliation":[{"name":"Centre Hospitalier Universitaire de Toulouse P\u00f4le Neurosciences Purpan ToNIC Universit\u00e9 de Toulouse Inserm, UPS Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Picaut","sequence":"additional","affiliation":[{"name":"Ipsen Innovation Les Ulis France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Volteau","sequence":"additional","affiliation":[{"name":"Ipsen Innovation Les Ulis France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Poewe","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University Innsbruck Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26760"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000142962.11881.26"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2010.03.002"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2012-001853"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S116325"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2007.01922.x"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fene.13800","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.13800","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ene.13800","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.13800","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T22:28:19Z","timestamp":1693348099000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.13800"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,30]]},"references-count":6,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1111\/ene.13800"],"URL":"https:\/\/doi.org\/10.1111\/ene.13800","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,30]]},"assertion":[{"value":"2017-12-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}