{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T01:49:18Z","timestamp":1770515358290,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,10,7]],"date-time":"2018-10-07T00:00:00Z","timestamp":1538870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005614","name":"Biogen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005614","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000381","name":"Multiple Sclerosis Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000381","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006447","name":"Universit\u00e4t Z\u00fcrich","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006447","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Fampridine leads to significant improvements in walking in many people with multiple sclerosis (Pw<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>). However, a relevant proportion of Pw<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> does not respond to fampridine and predictors of initial drug responsiveness are unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Drug response to prolonged\u2010release (<jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>)\u2010fampridine was assessed in 55 Pw<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> using the timed 25\u2010foot walk (T25FW), 6\u2010min walk test (6<jats:styled-content style=\"fixed-case\">MWT<\/jats:styled-content>) and 12\u2010item multiple sclerosis walking scale as outcome parameters. Patients were treated with <jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>\u2010fampridine and placebo for 6\u00a0weeks each in a randomized, double\u2010blind, placebo\u2010controlled trial with crossover design (<jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>01576354). Possible predictors of drug responsiveness were investigated by multiple correlation analysis and binary logistic regression models. An additional longitudinal analysis followed the drug responses of 32 patients treated with <jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>\u2010fampridine over 3\u00a0years to identify potential predictors of long\u2010term drug responsiveness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Severity of walking disability was positively correlated with enhanced responses to <jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>\u2010fampridine. The strongest single predictor of drug responsiveness was poor 6<jats:styled-content style=\"fixed-case\">MWT<\/jats:styled-content> performance at baseline, which was positively correlated with enhanced drug response in the 6<jats:styled-content style=\"fixed-case\">MWT<\/jats:styled-content> (<jats:italic>R<\/jats:italic>\u00a0=\u00a0\u22120.541; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). A multivariable logistic regression model including 6<jats:styled-content style=\"fixed-case\">MWT<\/jats:styled-content> and T25FW baseline performances predicted <jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>\u2010fampridine responder status with an accuracy of 85.5% (specificity, 90.0%; sensitivity, 73.3%), with a threshold of 211\u00a0m in the 6<jats:styled-content style=\"fixed-case\">MWT<\/jats:styled-content> best separating responders from non\u2010responders. Enhanced drug responsiveness after 3\u00a0years correlated with decline in walking endurance during this period (<jats:italic>R<\/jats:italic>\u00a0=\u00a0\u22120.634; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Initial walking impairment is a good predictor of therapeutic responsiveness to <jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>\u2010fampridine. Valid predictors of patients\u2019 responsiveness to <jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>\u2010fampridine are essential for patient stratification and optimization of multiple slcerosis treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13805","type":"journal-article","created":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T08:19:31Z","timestamp":1535789971000},"page":"281-289","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Predicting responsiveness to fampridine in gait\u2010impaired patients with multiple sclerosis"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3882-2504","authenticated-orcid":false,"given":"L.","family":"Filli","sequence":"first","affiliation":[{"name":"Department of Neurology University Hospital Zurich Zurich"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Werner","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Zurich Zurich"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Beyer","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Zurich Zurich"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Reuter","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Zurich Zurich"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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