{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T11:41:47Z","timestamp":1777117307150,"version":"3.51.4"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T00:00:00Z","timestamp":1544054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["FWF \u2013 P 29076"],"award-info":[{"award-number":["FWF \u2013 P 29076"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2019,2]]},"abstract":"\n Background and purpose<\/jats:title>\n \n Early pharmacological deep vein thrombosis (\n DVT<\/jats:styled-content>\n ) prophylaxis is recommended by guidelines, but rarely started within 48\u00a0h. We aimed to analyze the effect of early (within 48\u00a0h) versus late (>48\u00a0h)\n DVT<\/jats:styled-content>\n prophylaxis on hematoma expansion (\n HE<\/jats:styled-content>\n ) and outcome in patients with spontaneous intracerebral hemorrhage (\n ICH<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We analyzed 134 consecutive patients admitted to a tertiary neurointensive care unit with diagnosed spontaneous\n ICH<\/jats:styled-content>\n , without previous anticoagulation, severe coagulopathy, hematoma evacuation, early withdrawal of therapy or ineligibility for\n DVT<\/jats:styled-content>\n prophylaxis according to our institutional protocol. Significant late\n HE<\/jats:styled-content>\n was defined as \u22656\u00a0mL increase of hematoma volume between neuroimaging within 48\u00a0h and day 3\u20136. Multivariate analysis was performed to identify risk factors for late\n HE<\/jats:styled-content>\n , poor 3\u2010month outcome (modified Rankin Scale score\u00a0\u2265\u00a04) and mortality.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Patients had a median Glasgow Coma Scale score of 14 [interquartile range (\n IQR<\/jats:styled-content>\n ), 10\u201315],\n ICH<\/jats:styled-content>\n volume of 11 (\n IQR<\/jats:styled-content>\n , 5\u201324)\u00a0mL and were 71 (\n IQR<\/jats:styled-content>\n , 61\u201376)\u00a0years old. A total of 56% (\n n<\/jats:italic>\n \u00a0=\u00a076) received early\n DVT<\/jats:styled-content>\n prophylaxis, 37% (\n n<\/jats:italic>\n \u00a0=\u00a050) received late\n DVT<\/jats:styled-content>\n prophylaxis and 8 (6%) had unknown bleeding onset. Patients with early\n DVT<\/jats:styled-content>\n prophylaxis had smaller\n ICH<\/jats:styled-content>\n volume [9.5 (\n IQR<\/jats:styled-content>\n , 4\u201318.5) vs. 17.5 (\n IQR<\/jats:styled-content>\n , 8\u201329)\u00a0mL,\n P<\/jats:italic>\n \u00a0=\u00a00.038] and were more often comatose (26% vs. 10%,\n P<\/jats:italic>\n \u00a0=\u00a00.025). Significant late\n HE<\/jats:styled-content>\n [\n n<\/jats:italic>\n \u00a0=\u00a05\/134 (3.7%)] was associated with larger initial\n ICH<\/jats:styled-content>\n volume (\n P<\/jats:italic>\n \u00a0=\u00a00.02) and lower thrombocyte count (\n P<\/jats:italic>\n \u00a0=\u00a00.03) but not with early\n DVT<\/jats:styled-content>\n prophylaxis (\n P<\/jats:italic>\n \u00a0=\u00a00.36). Early\n DVT<\/jats:styled-content>\n prophylaxis was not associated with worse outcome.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Significant late\n HE<\/jats:styled-content>\n is uncommon and\n DVT<\/jats:styled-content>\n prophylaxis within 48\u00a0h of symptom onset may be safe in selected patients with\n ICH<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ene.13830","type":"journal-article","created":{"date-parts":[[2018,10,11]],"date-time":"2018-10-11T18:14:13Z","timestamp":1539281653000},"page":"333-341","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Early thrombosis prophylaxis with enoxaparin is not associated with hematoma expansion in patients with spontaneous intracerebral hemorrhage"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0705-4901","authenticated-orcid":false,"given":"B.","family":"Ianosi","sequence":"first","affiliation":[{"name":"Institute of Medical Informatics UMIT \u2013 University for Health Sciences, Medical Informatics and Technology Hall"},{"name":"Neurological Intensive Care Unit Department of Neurology Medical University of Innsbruck Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Gaasch","sequence":"additional","affiliation":[{"name":"Neurological Intensive Care Unit Department of Neurology Medical University of Innsbruck Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Rass","sequence":"additional","affiliation":[{"name":"Neurological Intensive Care Unit Department of Neurology Medical University of Innsbruck Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Huber","sequence":"additional","affiliation":[{"name":"Institute of Medical Informatics UMIT \u2013 University for Health Sciences, Medical Informatics and Technology Hall"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Hackl","sequence":"additional","affiliation":[{"name":"Institute of Medical Informatics UMIT \u2013 University for Health Sciences, Medical Informatics and Technology Hall"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Kofler","sequence":"additional","affiliation":[{"name":"Neurological Intensive Care Unit Department of Neurology Medical University of Innsbruck Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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