{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T07:25:18Z","timestamp":1789457118003,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,11,16]],"date-time":"2018-11-16T00:00:00Z","timestamp":1542326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Health utilities are a preference\u2010based method of valuing health states that are used in healthcare research, such as economic evaluations. There are limited health utility valuation data for patients with myasthenia gravis (MG). The aim of the study was to describe health utilities for patients with MG and different health states, using the EQ\u20105D\u20105L and SF\u20106D utility instruments, and to explore clinical and demographic determinants of utilities in this population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients completed the EQ\u20105D\u20105L and SF\u20106D. In addition, patients were assessed with the Myasthenia Gravis Foundation of America classification, Myasthenia Gravis Impairment Index and MG\u2010QOL15 as disease\u2010specific measures, and the Neuro\u2010QoL Fatigue scale. We calculated mean utilities for each Myasthenia Gravis Foundation of America severity class. We built regression models for the EQ\u20105D\u20105L and SF\u20106D to determine the clinical and demographic factors that determine patients\u2019 valuation of their health state.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 254 patients, mean EQ\u20105D\u20105L health utilities were as follows: Remission, 0.94\u00a0\u00b1\u00a00.03; Minimal Manifestations, 0.92\u00a0\u00b1\u00a00.04; Class I, 0.89\u00a0\u00b1\u00a00.06; Class II, 0.78\u00a0\u00b1\u00a00.16; Class III, 0.58\u00a0\u00b1\u00a00.24 and Class IV, 0.61\u00a0\u00b1\u00a00.22. Mean SF\u20106D health utilities were as follows: Remission, 0.83\u00a0\u00b1\u00a00.07; Minimal Manifestations, 0.86\u00a0\u00b1\u00a00.14; Class I, 0.82\u00a0\u00b1\u00a00.14; Class II, 0.67\u00a0\u00b1\u00a00.12; Class III, 0.56\u00a0\u00b1\u00a00.11 and Class IV, 0.50\u00a0\u00b1\u00a00.10. The limb\/axial scores were more highly correlated to health utilities than ocular or bulbar scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We present estimates of health utilities for patients with MG that can be used in cost\u2010utility and decision analyses. Limb\/axial symptoms had a higher impact on health utilities than ocular or bulbar symptoms, which might reflect the impact of mobility on health valuation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13836","type":"journal-article","created":{"date-parts":[[2018,10,13]],"date-time":"2018-10-13T13:00:21Z","timestamp":1539435621000},"page":"452-459","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["EQ\u20105D\u20105L and SF\u20106D health utility index scores in patients with myasthenia gravis"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5546-0221","authenticated-orcid":false,"given":"C.","family":"Barnett","sequence":"first","affiliation":[{"name":"Division of Neurology Department of Medicine University of Toronto and University Health Network Toronto ON"},{"name":"Institute of Health Policy, Management and Evaluation University of Toronto Toronto ON"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Bril","sequence":"additional","affiliation":[{"name":"Division of Neurology Department of Medicine University of Toronto and University Health Network Toronto ON"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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