{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T02:44:37Z","timestamp":1787453077805,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,11,18]],"date-time":"2018-11-18T00:00:00Z","timestamp":1542499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2019,3]]},"abstract":"\n Background and purpose<\/jats:title>\n \n Weight loss (\n WL<\/jats:styled-content>\n ) is a frequent yet under\u2010recognized complication of levodopa\/carbidopa intestinal gel (\n LCIG<\/jats:styled-content>\n ) infusion, as well as a milestone of Parkinson's disease (\n PD<\/jats:styled-content>\n ) disability progression. The complex association between WL, poor nutritional status, motor complications and\n PD<\/jats:styled-content>\n progression, however, remains unclear.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Consecutive consenting patients with\n PD<\/jats:styled-content>\n treated with\n LCIG<\/jats:styled-content>\n (\n n<\/jats:italic>\n \u00a0=\u00a044;\n PD<\/jats:styled-content>\n duration, 18.3\u00a0\u00b1\u00a06.5\u00a0years) were enrolled in an open\u2010label observational study assessing the extent of\n WL<\/jats:styled-content>\n occurring during\n LCIG<\/jats:styled-content>\n treatment. As secondary aims, we correlated the nutritional status, as detected by the Mini Nutritional Assessment, with the severity of motor symptoms [Movement Disorder Society Unified Parkinson's Disease Rating Scale part\n III<\/jats:styled-content>\n ], motor complications (Unified Parkinson's Disease Rating Scale part IV), activities of daily living (Schwab and England scale), cognitive impairment (Mini Mental State Examination), depression (Beck Depression Inventory), difficulties in feeding (Edinburgh Feeding Evaluation in Dementia Questionnaire) and levodopa equivalent daily dose (\n LEDD<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n There was an average\n WL<\/jats:styled-content>\n of 9.9\u00a0\u00b1\u00a010.5% (7.6\u00a0\u00b1\u00a07.1\u00a0kg) over an\n LCIG<\/jats:styled-content>\n treatment period of 51.6\u00a0\u00b1\u00a028.5\u00a0months. The extent of\n WL<\/jats:styled-content>\n correlated with the percentage of the waking day spent with dyskinesia (\n P<\/jats:italic>\n \u00a0<\u00a00.05). The nutritional status correlated with motor symptom severity (\n P<\/jats:italic>\n \u00a0<\u00a00.01), dysphagia (\n P<\/jats:italic>\n \u00a0<\u00a00.01) and\n LEDD<\/jats:styled-content>\n (\n P<\/jats:italic>\n \u00a0<\u00a00.01).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Weight loss may occur in patients with\n PD<\/jats:styled-content>\n undergoing\n LCIG<\/jats:styled-content>\n in correlation with the percentage of the waking day spent with dyskinesia. Regardless of the extent of\n WL<\/jats:styled-content>\n , the nutritional status correlated with higher\n LEDD<\/jats:styled-content>\n , as well as with indices of disease progression, such as motor symptom severity and dysphagia.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ene.13844","type":"journal-article","created":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T18:10:41Z","timestamp":1540231841000},"page":"490-496","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Levodopa\/carbidopa intestinal gel infusion and weight loss in Parkinson's disease"],"prefix":"10.1111","volume":"26","author":[{"given":"M.","family":"Fabbri","sequence":"first","affiliation":[{"name":"Instituto de Medicina Molecular Faculty of Medicine University of Lisbon Lisbon Portugal"},{"name":"Department of Neuroscience \u2018Rita Levi Montalcini\u2019 University of Torino Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2939-343X","authenticated-orcid":false,"given":"M.","family":"Zibetti","sequence":"additional","affiliation":[{"name":"Department of Neuroscience \u2018Rita Levi Montalcini\u2019 University of Torino Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Beccaria","sequence":"additional","affiliation":[{"name":"Department of Neuroscience \u2018Rita Levi Montalcini\u2019 University of Torino Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Merola","sequence":"additional","affiliation":[{"name":"Gardner Family Center for Parkinson's Disease and Movement Disorders Department of Neurology University of Cincinnati Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1312-1843","authenticated-orcid":false,"given":"A.","family":"Romagnolo","sequence":"additional","affiliation":[{"name":"Department of Neuroscience \u2018Rita Levi Montalcini\u2019 University of Torino Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Montanaro","sequence":"additional","affiliation":[{"name":"Department of Neuroscience \u2018Rita Levi Montalcini\u2019 University of Torino Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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