{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T19:50:30Z","timestamp":1784922630285,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T00:00:00Z","timestamp":1543795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Dysphagia occurs in up to 50% of all patients with acute stroke. There is debate regarding which is the most effective screening tool in identifying aspiration in patients with acute stroke. We assessed the accuracy of the Sapienza Global Bedside Evaluation of Swallowing after Stroke (<jats:styled-content style=\"fixed-case\">GLOBE<\/jats:styled-content>\u20103S), which combines the Toronto Bedside Swallowing Screening Test (<jats:styled-content style=\"fixed-case\">TOR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">BSST<\/jats:styled-content>\u00a9) with oxygen desaturation and laryngeal elevation measurement during swallowing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively enrolled consecutive patients with stroke within 72 h of symptom onset. All patients with stroke firstly underwent a standard neurological examination, then the<jats:styled-content style=\"fixed-case\">GLOBE<\/jats:styled-content>\u20103S evaluation and finally the fiberoptic endoscopic evaluation of swallowing (<jats:styled-content style=\"fixed-case\">FEES<\/jats:styled-content>). Two different assessors, a neurologist and a speech pathologist, blind to both the clinical data and each other's evaluation, administered the<jats:styled-content style=\"fixed-case\">GLOBE<\/jats:styled-content>\u20103S and<jats:styled-content style=\"fixed-case\">FEES<\/jats:styled-content>examination. We assessed the accuracy of the<jats:styled-content style=\"fixed-case\">GLOBE<\/jats:styled-content>\u20103S in detecting post\u2010stroke swallow impairment with aspiration using the<jats:styled-content style=\"fixed-case\">FEES<\/jats:styled-content>as the standard.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We enrolled 50 patients with acute stroke, 28 of whom (56%) had swallowing impairment with aspiration at<jats:styled-content style=\"fixed-case\">FEES<\/jats:styled-content>evaluation. A total of 33 patients (66%) failed the<jats:styled-content style=\"fixed-case\">GLOBE<\/jats:styled-content>\u20103S evaluation. The<jats:styled-content style=\"fixed-case\">GLOBE<\/jats:styled-content>\u20103S reached a sensitivity of 100% and a specificity of 77.3% (negative predictive value, 100%; positive likelihood ratio, 4.34). The median time required for the<jats:styled-content style=\"fixed-case\">GLOBE<\/jats:styled-content>\u20103S to be performed was 297 s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">GLOBE<\/jats:styled-content>\u20103S is quick to perform at the bedside and can accurately identify aspiration in patients with acute stroke. By including the measurement of laryngeal elevation and monitoring of oxygen desaturation, it could represent a highly sensitive instrument to avoid the misdiagnosis of silent aspirators.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13862","type":"journal-article","created":{"date-parts":[[2018,11,10]],"date-time":"2018-11-10T10:59:56Z","timestamp":1541847596000},"page":"596-602","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Sapienza Global Bedside Evaluation of Swallowing after Stroke: the<scp>GLOBE<\/scp>\u20103S study"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0120-1782","authenticated-orcid":false,"given":"M.","family":"Toscano","sequence":"first","affiliation":[{"name":"Department of Human Neuroscience \u2018Sapienza\u2019 University of Rome Rome Italy"},{"name":"Department of Neurology Fatebenefratelli Hospital Isola Tiberina Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Vigan\u00f2","sequence":"additional","affiliation":[{"name":"Department of Human Neuroscience \u2018Sapienza\u2019 University of Rome Rome Italy"},{"name":"Department of Anatomy Histology, Forensic Medicine and Orthopaedics \u2018Sapienza\u2019 University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Rea","sequence":"additional","affiliation":[{"name":"Department of Sensorial Organs \u2018Sapienza\u2019 University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9322-1165","authenticated-orcid":false,"given":"A.","family":"Verzina","sequence":"additional","affiliation":[{"name":"Neurology Clinic University of Perugia \u2013 Perugia General Hospital Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Sasso D'Elia","sequence":"additional","affiliation":[{"name":"Physical Medicine and Rehabilitation Division \u2018Sapienza\u2019 University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Puledda","sequence":"additional","affiliation":[{"name":"Institute of Psychiatry, Psychology and Neuroscience King's College of London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Longo","sequence":"additional","affiliation":[{"name":"Department of Sensorial Organs \u2018Sapienza\u2019 University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4411-896X","authenticated-orcid":false,"given":"V.","family":"Mancini","sequence":"additional","affiliation":[{"name":"Department of Human Neuroscience \u2018Sapienza\u2019 University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ruggiero","sequence":"additional","affiliation":[{"name":"Department of Human Neuroscience \u2018Sapienza\u2019 University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. B.","family":"Jannini","sequence":"additional","affiliation":[{"name":"Department of Human Neuroscience \u2018Sapienza\u2019 University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Giuliani","sequence":"additional","affiliation":[{"name":"Department of Human Neuroscience \u2018Sapienza\u2019 University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Albino","sequence":"additional","affiliation":[{"name":"Department of Sensorial Organs \u2018Sapienza\u2019 University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Altieri","sequence":"additional","affiliation":[{"name":"Department of Human Neuroscience \u2018Sapienza\u2019 University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Vicenzini","sequence":"additional","affiliation":[{"name":"Department of Human Neuroscience \u2018Sapienza\u2019 University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Fattapposta","sequence":"additional","affiliation":[{"name":"Department of Sensorial Organs \u2018Sapienza\u2019 University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Pauri","sequence":"additional","affiliation":[{"name":"Department of Sensorial Organs \u2018Sapienza\u2019 University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Giacomini","sequence":"additional","affiliation":[{"name":"Department of Sensorial Organs \u2018Sapienza\u2019 University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Ruoppolo","sequence":"additional","affiliation":[{"name":"Department of Sensorial Organs \u2018Sapienza\u2019 University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Di Piero","sequence":"additional","affiliation":[{"name":"Department of Human Neuroscience \u2018Sapienza\u2019 University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1747493016639057"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000441056"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.640946"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000158"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.510370"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.638254"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2018.14.3.265"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-017-9868-1"},{"key":"e_1_2_7_10_1","doi-asserted-by":"crossref","first-page":"790","DOI":"10.47102\/annals-acadmedsg.V32N6p790","article-title":"Bedside clinical methods useful as screening test for aspiration in elderly patients with recent and previous strokes","volume":"32","author":"Chong MS","year":"2003","journal-title":"Ann Acad Med Singapore"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004550000038"},{"key":"e_1_2_7_12_1","volume-title":"Evaluation and Treatment of Swallowing Disorders,","author":"Logemann JA","year":"1997"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1564721"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2017.04.003"},{"key":"e_1_2_7_15_1","article-title":"Laryngeal elevation velocity and aspiration in acute ischemic stroke patients","volume":"11","author":"Zhang J","year":"2016","journal-title":"PLoS ONE"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.4037\/ajcc2009961"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/27.2.99"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.4103\/0028-3886.60395"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02414429"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00417897"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000190056.76543.eb"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000177529.86868.8d"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-005-0018-9"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1466-7657.2006.00460.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-016-9702-1"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fene.13862","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.13862","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ene.13862","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.13862","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T07:19:17Z","timestamp":1720768757000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.13862"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,3]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["10.1111\/ene.13862"],"URL":"https:\/\/doi.org\/10.1111\/ene.13862","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,3]]},"assertion":[{"value":"2018-04-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}