{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T23:10:36Z","timestamp":1773270636856,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,12,17]],"date-time":"2018-12-17T00:00:00Z","timestamp":1545004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009101","name":"Education Department of Henan Province","doi-asserted-by":"publisher","award":["16A320054"],"award-info":[{"award-number":["16A320054"]}],"id":[{"id":"10.13039\/501100009101","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009101","name":"Education Department of Henan Province","doi-asserted-by":"publisher","award":["172102310086"],"award-info":[{"award-number":["172102310086"]}],"id":[{"id":"10.13039\/501100009101","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571158"],"award-info":[{"award-number":["81571158"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Several clinical trials have demonstrated that dual antiplatelet therapy (DAPT) benefited patients with transient ischaemic attack (TIA) with an ABCD2 score \u22654. The present study aimed to investigate whether the ABCD3\u2010I score could be a more appropriate tool for selection of patients with TIA to receive DAPT in real\u2010world settings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We derived data from the TIA database of The First Affiliated Hospital of Zhengzhou University. The predictive outcome was ischaemic stroke at 90\u00a0days. The additive interaction effect was presented by the attributable proportion due to interaction. Kaplan\u2013Meier curves were plotted to present cumulative stroke rates in different risk categories with monotherapy and DAPT. Cox proportional hazards regression was used to determine risk factors associated with stroke.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 785 patients, the mean (SD) age was 56.95 (12.73) years and 77 patients (9.8%) had an ischaemic stroke at 90\u00a0days. A total of 55.8% of patients (attributable proportion due to interaction; 95% confidence interval, 20.8%\u201390.9%) were attributed to additive interaction of ABCD3\u2010I score and antiplatelet therapy. Kaplan\u2013Meier curves showed a significant difference between patients receiving monotherapy and DAPT in high\u2010risk patients with TIA (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.021). DAPT reduced 90\u2010day stroke risk in high\u2010risk patients with TIA as assessed independently by ABCD3\u2010I score (adjusted hazard ratio, 0.43; 95% confidence interval, 0.20\u20130.92, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.031). The benefit did not exist in low\u2010 and medium\u2010risk patients by ABCD3\u2010I score (patients with ABCD2 score\u00a0\u2265\u00a04 or &lt;4).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>High\u2010risk patients with TIA assessed by ABCD3\u2010I score received the most pronounced clinical benefit from early use of DAPT in real\u2010world clinical experience.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13864","type":"journal-article","created":{"date-parts":[[2018,11,10]],"date-time":"2018-11-10T11:20:16Z","timestamp":1541848816000},"page":"610-616","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Dual antiplatelet therapy reduced stroke risk in high\u2010risk patients with transient ischaemic attack assessed by ABCD3\u2010I score"],"prefix":"10.1111","volume":"26","author":[{"given":"B.","family":"Song","sequence":"first","affiliation":[{"name":"Department of Neurology The First 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