{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:49:31Z","timestamp":1787014171661,"version":"build-2736575974"},"reference-count":11,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,12,17]],"date-time":"2018-12-17T00:00:00Z","timestamp":1545004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"\n Background and purpose<\/jats:title>\n \n Myasthenia gravis activities of daily living (MG\u2010ADL) is a commonly used questionnaire in MG trials. To investigate whether\n MG<\/jats:styled-content>\n \u2010\n ADL<\/jats:styled-content>\n is equally sensitive to oculobulbar and generalized weakness, its correlation with the oculobulbar and generalized domain of the quantitative myasthenia gravis (\n QMG<\/jats:styled-content>\n ) score was analyzed (\n QMG<\/jats:styled-content>\n ob and\n QMG<\/jats:styled-content>\n gen, respectively). To test whether the sensitivity of\n MG<\/jats:styled-content>\n \u2010\n ADL<\/jats:styled-content>\n for generalized weakness could be improved, the additional value of ACTIVLIM on top of MG\u2010ADL in the prediction QMGgen in was investigated.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n MG\u2010ADL,\n QMG<\/jats:styled-content>\n and\n ACTIVLIM<\/jats:styled-content>\n , an\n ADL<\/jats:styled-content>\n questionnaire focusing on generalized weakness, were analyzed in a prospective cohort of 112\n MG<\/jats:styled-content>\n patients. A generalized linear model was used to calculate the correlation of\n MG<\/jats:styled-content>\n \u2010\n ADL<\/jats:styled-content>\n with\n QMG<\/jats:styled-content>\n ob and\n QMG<\/jats:styled-content>\n gen and to assess the additional value of\n ACTIVLIM<\/jats:styled-content>\n on top of\n MG<\/jats:styled-content>\n \u2010\n ADL<\/jats:styled-content>\n for its correlation with\n QMG<\/jats:styled-content>\n gen.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n MG\u2010ADL had a higher correlation with\n QMG<\/jats:styled-content>\n ob than with\n QMG<\/jats:styled-content>\n gen (\n B<\/jats:italic>\n = 0.68,\n P<\/jats:italic>\n < 0.001, and\n B<\/jats:italic>\n = 0.38,\n P<\/jats:italic>\n < 0.001, respectively). A similar trend was found for changes in the scores (\n B<\/jats:italic>\n = 0.68,\n P<\/jats:italic>\n = 0.132, and\n B<\/jats:italic>\n = 0.39,\n P<\/jats:italic>\n = 0.492, respectively).\n ACTIVLIM<\/jats:styled-content>\n had a significant additional value on top of\n MG<\/jats:styled-content>\n \u2010\n ADL<\/jats:styled-content>\n in the prediction of\n QMG<\/jats:styled-content>\n gen, both cross\u2010sectionally (\n B<\/jats:italic>\n = \u22120.61,\n P<\/jats:italic>\n < 0.001) and for changes within individual patients (\n B<\/jats:italic>\n = \u22120.93,\n P<\/jats:italic>\n = 0.041).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n MG\u2010ADL has a lower sensitivity for generalized weakness than for oculobulbar weakness. Adding questions on generalized weakness would improve the sensitivity of the\n MG<\/jats:styled-content>\n \u2010\n ADL<\/jats:styled-content>\n for generalized weakness.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ene.13867","type":"journal-article","created":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T07:05:27Z","timestamp":1542006327000},"page":"947-950","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Sensitivity of MG\u2010ADL for generalized weakness in myasthenia gravis"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4374-3715","authenticated-orcid":false,"given":"R. H. P.","family":"de Meel","sequence":"first","affiliation":[{"name":"Department of Neurology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. F.","family":"Raadsheer","sequence":"additional","affiliation":[{"name":"Department of Neurology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. W.","family":"van Zwet","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4572-1501","authenticated-orcid":false,"given":"J. J. G. M.","family":"Verschuuren","sequence":"additional","affiliation":[{"name":"Department of Neurology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. R.","family":"Tannemaat","sequence":"additional","affiliation":[{"name":"Department of Neurology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70063-8"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3233\/JND-160148"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002795"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30369-1"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004365"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.52.7.1487"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30037-1"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.25463"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2007.02.013"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004676"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2008.11.004"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fene.13867","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.13867","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ene.13867","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.13867","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T18:28:18Z","timestamp":1693333698000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.13867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,17]]},"references-count":11,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1111\/ene.13867"],"URL":"https:\/\/doi.org\/10.1111\/ene.13867","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,17]]},"assertion":[{"value":"2018-09-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}