{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:33:48Z","timestamp":1790404428256,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T00:00:00Z","timestamp":1545091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Diffusion\u2010weighted imaging (<jats:styled-content style=\"fixed-case\">DWI<\/jats:styled-content>) commonly detects acute ischaemic lesions in patients with acute intracerebral hemorrhage (<jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content>), especially with cerebral amyloid angiopathy (<jats:styled-content style=\"fixed-case\">CAA<\/jats:styled-content>). We investigated the relationship between cortical superficial siderosis (<jats:styled-content style=\"fixed-case\">cSS<\/jats:styled-content>), a neuroimaging marker of <jats:styled-content style=\"fixed-case\">CAA<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">DWI<\/jats:styled-content> lesions in patients with acute <jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective analysis of prospectively collected data from consecutive patients with acute supratentorial <jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content> who underwent brain magnetic resonance imaging within 10\u00a0days after symptom onset. Magnetic resonance imaging scans were analyzed for <jats:styled-content style=\"fixed-case\">DWI<\/jats:styled-content> lesions, <jats:styled-content style=\"fixed-case\">cSS<\/jats:styled-content> and other markers for small\u2010vessel disease. Univariate and multivariate analyses were performed to assess the association between <jats:styled-content style=\"fixed-case\">cSS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">DWI<\/jats:styled-content> lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 246 <jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content> survivors (mean age 71.4\u00a0\u00b1\u00a012.6\u00a0years) who were enrolled, 126 had lobar <jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content> and 120 had deep <jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content>. Overall, <jats:styled-content style=\"fixed-case\">DWI<\/jats:styled-content> lesions were observed in 38 (15.4%) patients and were more common in patients with lobar <jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content> than deep <jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content> (22.2% vs. 8.3%; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.003). In multivariate logistic regression analysis, the extent of white matter hyperintensities [odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>), 1.29; 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI)<\/jats:styled-content>, 1.05\u20131.58; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.02] and <jats:styled-content style=\"fixed-case\">cSS<\/jats:styled-content> severity (focal <jats:styled-content style=\"fixed-case\">cSS<\/jats:styled-content>:<jats:styled-content style=\"fixed-case\"> OR,<\/jats:styled-content> 3.54; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.28\u20139.84; disseminated <jats:styled-content style=\"fixed-case\">cSS<\/jats:styled-content>:<jats:styled-content style=\"fixed-case\"> OR,<\/jats:styled-content> 4.41; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.78\u201310.97; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.001) were independently associated with the presence of <jats:styled-content style=\"fixed-case\">DWI<\/jats:styled-content> lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Diffusion\u2010weighted imaging lesions are more frequently observed in patients with acute lobar <jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content> than in those with deep <jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">cSS<\/jats:styled-content> severity and white matter hyperintensity extent are independent predictors for the presence of <jats:styled-content style=\"fixed-case\">DWI<\/jats:styled-content> lesions, suggesting that <jats:styled-content style=\"fixed-case\">CAA<\/jats:styled-content> may be involved in the pathogenesis of <jats:styled-content style=\"fixed-case\">DWI<\/jats:styled-content> lesions associated with acute <jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13874","type":"journal-article","created":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T12:42:55Z","timestamp":1545136975000},"page":"660-666","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Acute ischaemic lesions are associated with cortical superficial siderosis in spontaneous intracerebral hemorrhage"],"prefix":"10.1111","volume":"26","author":[{"given":"P.","family":"Revel\u2010Mouroz","sequence":"first","affiliation":[{"name":"Neuroradiology Department H\u00f4pital Pierre\u2010Paul Riquet Centre Hospitalier Universitaire de Toulouse Toulouse"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Viguier","sequence":"additional","affiliation":[{"name":"Neurology Department H\u00f4pital Pierre\u2010Paul Riquet Centre Hospitalier Universitaire de Toulouse Toulouse"},{"name":"Toulouse NeuroImaging Center Universit\u00e9 de Toulouse Inserm, UPS Toulouse"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Cazzola","sequence":"additional","affiliation":[{"name":"Neuroradiology Department H\u00f4pital Pierre\u2010Paul Riquet Centre Hospitalier Universitaire de Toulouse Toulouse"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Calviere","sequence":"additional","affiliation":[{"name":"Neurology Department H\u00f4pital Pierre\u2010Paul Riquet Centre Hospitalier Universitaire de Toulouse Toulouse"},{"name":"Toulouse NeuroImaging Center Universit\u00e9 de Toulouse Inserm, UPS Toulouse"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Patsoura","sequence":"additional","affiliation":[{"name":"Neuroradiology Department H\u00f4pital Pierre\u2010Paul Riquet Centre Hospitalier Universitaire de Toulouse Toulouse"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Rousseau","sequence":"additional","affiliation":[{"name":"Epidemiology Department Centre Hospitalier Universitaire de Toulouse Toulouse"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Sommet","sequence":"additional","affiliation":[{"name":"Epidemiology Department Centre Hospitalier Universitaire de Toulouse Toulouse"},{"name":"Department of Clinical Pharmacology CIC1436, USMR Centre Hospitalier Universitaire de Toulouse Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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