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This study aimed to assess the association between non\u2010HDLC levels and the prevalence of asymptomatic extracranial internal carotid artery stenosis (EICAS) as well as the predictive value of non\u2010HDLC over LDLC on EICAS presence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Asymptomatic Polyvascular Abnormalities Community study is a subset of the Kailuan study emphasizing asymptomatic polyvascular abnormalities in Chinese adults. A total of 5351 participants, aged \u226540, without history of cardiovascular disease were enrolled in this study. Carotid duplex ultrasonography was carried out for the detection of EICAS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 5351 patients, 2.5% (131\/5351) were diagnosed with EICAS (stenosis \u226550%). Univariate analysis showed that non\u2010HDLC is an independent indicator for asymptomatic EICAS [odds ratio (OR) 1.49, 95% confidence interval (CI) 1.17\u20131.91]; the same result was reached in multivariate analysis after adjustment for confounding factors (OR 1.32, 95% CI 1.00\u20131.75), especially for people with hypertension (OR 1.52, 95% CI 1.11\u20132.08), whilst non\u2010HDLC failed to show better predictive value of EICAS than LDLC (OR 1.45, 95% CI 1.02\u20132.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Non\u2010HDLC is an independent risk factor for EICAS prevalence, especially for hypertension patients. Although the predictive value of non\u2010HDLC was no better than LDLC on EICAS presence, non\u2010HDLC is still a powerful atherogenic factor and potential therapeutic target for EICAS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13882","type":"journal-article","created":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T15:53:49Z","timestamp":1545148429000},"page":"740-746","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Association between non\u2010high\u2010density lipoprotein cholesterol levels and the prevalence of asymptomatic extracranial internal carotid artery stenosis in a Chinese community\u2010based study"],"prefix":"10.1111","volume":"26","author":[{"given":"J.","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Neurology Beijing Tiantan Hospital Capital Medical University Beijing China"},{"name":"China National Clinical Research Center for Neurological Diseases Beijing China"},{"name":"Center of Stroke Beijing Institute for Brain Disorders Beijing China"},{"name":"Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology Beijing Tiantan Hospital Capital Medical University Beijing China"},{"name":"China National Clinical Research Center for Neurological Diseases Beijing China"},{"name":"Center of Stroke Beijing Institute for Brain Disorders Beijing China"},{"name":"Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4351-2877","authenticated-orcid":false,"given":"A.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology Beijing Tiantan Hospital Capital Medical University Beijing China"},{"name":"Department of Epidemiology and Health Statistics School of Public Health Capital Medical University Beijing China"},{"name":"Beijing Municipal Key Laboratory of Clinical Epidemiology Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Neurology Beijing Tiantan Hospital Capital Medical University Beijing China"},{"name":"China National Clinical Research Center for Neurological Diseases Beijing China"},{"name":"Center of Stroke Beijing Institute for Brain Disorders Beijing China"},{"name":"Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology Beijing Tiantan Hospital Capital Medical University Beijing China"},{"name":"China National Clinical Research Center for Neurological Diseases Beijing China"},{"name":"Center of Stroke Beijing Institute for Brain Disorders Beijing China"},{"name":"Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8636-9540","authenticated-orcid":false,"given":"X.","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology Beijing Tiantan Hospital Capital Medical University Beijing China"},{"name":"China National Clinical Research Center for Neurological Diseases Beijing China"},{"name":"Center of Stroke Beijing Institute for Brain Disorders Beijing China"},{"name":"Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.635755"},{"key":"e_1_2_8_3_1","unstructured":"ScarboroughP PetoV BhatnagarP et\u00a0al.Stroke Statistics. 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