{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:50:49Z","timestamp":1793386249790,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,1,20]],"date-time":"2019-01-20T00:00:00Z","timestamp":1547942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>The prognosis of status epilepticus (<jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>) depends on the time between onset and the diagnosis and start of treatment. Our aim was to design a scale with predictive value for pre\u2010hospital diagnosis of <jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective study of 292 patients who attended the emergency department for an epileptic seizure. A total of 49 patients fulfilled the criteria for <jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>. We recorded the patients\u2019 history and clinical features. Variables independently associated with <jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content> were combined to design a clinical scale. The performance of the scale was evaluated in a validation dataset of 197 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 50.3% of the patients were male and the mean age was 55.9\u00a0years. The following features were more prevalent in patients with <jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>: abnormal speech (79.6% vs. 18.9%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), eye deviation (69.4% vs. 14.0%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), automatism (22.4% vs. 6.3%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), hemiparesis (24.5% vs. 10.9%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.011), state of stupor\/coma (46.9% vs. 4.2%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and number of pre\u2010hospital seizures, i.e. two (34.7% vs. 4.5%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) or more than two (51.0% vs. 0.4%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Based on these findings, we designed a scale that scored 1 point each for presence of abnormal speech, eye deviation, automatism and two seizures, and 2 points for more than two seizures. The predictive capacity of the scale for identifying <jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content> in the validation dataset was 98.7% (95% confidence interval, 97.3%\u2013100%) and 85.4% of patients with a score &gt;1 had <jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A score &gt;1 on the <jats:styled-content style=\"fixed-case\">ADAN<\/jats:styled-content> scale is a robust predictor of the diagnosis of <jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content> in patients who experience an epileptic seizure. This scale may be a useful tool for clinical use and warrants further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13885","type":"journal-article","created":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T06:40:26Z","timestamp":1545201626000},"page":"760","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["The ADAN scale: a proposed scale for pre\u2010hospital use to identify status epilepticus"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5671-6484","authenticated-orcid":false,"given":"M.","family":"Requena","sequence":"first","affiliation":[{"name":"Epilepsy Unit Hospital Universitario Vall d'Hebron Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Epilepsy Unit Hospital Universitario Vall d'Hebron Barcelona 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