{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T14:31:20Z","timestamp":1774276280178,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T00:00:00Z","timestamp":1550534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Peripapillary retinal nerve fibre layer (pRNFL) thickness is a strong candidate as a biomarker of axonal degeneration in multiple sclerosis (MS). The aim was to determine a cut\u2010off value of pRNFL thinning rates in relapsing\u2013remitting MS (RRMS) to discriminate between stable and progressing patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this 3\u2010year prospective longitudinal study on 141 RRMS patients, annual pRNFL thinning rates (aLpRNFL) were determined by individual linear regression models. The best possible cut\u2010off value discriminating clinically progressing (physical progression or cognitive decline) and stable patients was defined by receiver operating characteristic analysis. Cut\u2010off values were validated using a multivariate logistic regression model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Average aLpRNFL in progressing patients (2.4\u00a0\u03bcm, SD 2.1) was significantly higher compared to stable patients (0.5\u00a0\u03bcm, SD 1.2, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). At a predefined specificity of 90%, aLpRNFL &gt;1.5\u00a0\u03bcm was able to distinguish between stable and progressing RRMS with a sensitivity of 76.1%. aLpRNFL &gt;1.5\u00a0\u03bcm was associated with a 15\u2010fold increased risk of clinically progressing MS (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A cut\u2010off of aLpRNFL discriminating clinically progressing and stable RRMS was identified. After validation in independent cohorts, this cut\u2010off could be used as a biomarker of axonal degeneration supporting disease monitoring in daily clinical routine.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13897","type":"journal-article","created":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T20:52:48Z","timestamp":1546980768000},"page":"865-871","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Peripapillary retinal nerve fibre layer thinning rate as a biomarker discriminating stable and progressing relapsing\u2013remitting multiple sclerosis"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0825-0851","authenticated-orcid":false,"given":"G.","family":"Bsteh","sequence":"first","affiliation":[{"name":"Department of Neurology Medical University of Innsbruck Innsbruck 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