{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T20:30:14Z","timestamp":1790368214967,"version":"4.1.0"},"reference-count":9,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,3,5]],"date-time":"2019-03-05T00:00:00Z","timestamp":1551744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2019,7]]},"abstract":"Background and purpose<\/jats:title>Because of their potential to alter the integrity of collagen and other components of the extracellular matrix, fluoroquinolone antibiotics might be involved in the pathogenesis of spontaneous cervical artery dissection (sCeAD<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>In the setting of a single\u2010centre case\u2013control study, whether fluoroquinolone use in the 30\u2010day period before the index event is associated with sCeAD<\/jats:styled-content> (cases) in comparison with a group of age\u2010 and sex\u2010matched patients who suffered a first\u2010ever acute cerebral infarction from a cause other than CeAD<\/jats:styled-content> (non\u2010CeAD IS<\/jats:styled-content>, controls) was assessed.<\/jats:p><\/jats:sec>Results<\/jats:title>Overall, 284 cases (mean age 43.2\u00a0\u00b1\u00a010.4\u00a0years; 58.5% men) and 568 controls qualified for the analysis. Thirty (10.6%) patients in the sCeAD<\/jats:styled-content> group and 16 (2.8%) in the non\u2010CeAD IS<\/jats:styled-content> group were fluoroquinolone users (P<\/jats:italic>\u00a0\u2264\u00a00.001). The use of these antibiotics was associated with a more than two\u2010fold increased risk of sCeAD<\/jats:styled-content> [odds ratio (OR<\/jats:styled-content>) 2.31; 95% confidence interval (CI<\/jats:styled-content>) 1.00\u20135.30] after adjusting for confounders. The risk was more substantial in the subgroup of patients with dissection involving the carotid artery (OR<\/jats:styled-content> 2.78; 95% CI<\/jats:styled-content> 1.14\u20136.78), in females (OR<\/jats:styled-content> 4.58; 95% CI<\/jats:styled-content> 1.04\u201320.1) and compared to that conferred by other antibiotics (OR<\/jats:styled-content> 2.42; 95% CI<\/jats:styled-content> 1.02\u20135.75).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Fluoroquinolones may represent a novel contributing factor involved in the pathogenesis of sCeAD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13917","type":"journal-article","created":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T04:09:01Z","timestamp":1548821341000},"page":"1028-1031","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Use of fluoroquinolones and the risk of spontaneous cervical artery dissection"],"prefix":"10.1111","volume":"26","author":[{"given":"E.","family":"Del Zotto","sequence":"first","affiliation":[{"name":"U.O. Neurologia Istituto Ospedaliero Poliambulanza Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8629-3315","authenticated-orcid":false,"given":"A.","family":"Pezzini","sequence":"additional","affiliation":[{"name":"U.O. Neurologia Istituto Ospedaliero Poliambulanza Brescia Italy"},{"name":"Dipartimento di Scienze Cliniche e Sperimentali Clinica Neurologica Universit\u00e0 degli Studi di Brescia Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-013-0089-8"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2015.5389"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-010077"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2017.06.029"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k678"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000056"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2016.5704"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2018.1804"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.24.1.35"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fene.13917","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.13917","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T13:07:38Z","timestamp":1694351258000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.13917"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,5]]},"references-count":9,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1111\/ene.13917"],"URL":"https:\/\/doi.org\/10.1111\/ene.13917","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,5]]},"assertion":[{"value":"2018-10-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}