{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T14:37:35Z","timestamp":1759847855067,"version":"3.37.3"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,2,21]],"date-time":"2019-02-21T00:00:00Z","timestamp":1550707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2019,7]]},"abstract":"Background and purpose<\/jats:title>Elevation of cardiac troponin (cT<\/jats:styled-content>n), a sensitive biomarker of myocardial injury, is frequently observed in severe acute neurological disorders. Case reports suggest that cardiac dysfunction may also occur in patients with transient global amnesia (TGA<\/jats:styled-content>). Until now, no study has systematically assessed this phenomenon.<\/jats:p><\/jats:sec>Methods<\/jats:title>We performed a case\u2010control study using data of consecutive patients presenting with TGA<\/jats:styled-content> from 2010 to 2015. Multiple logistic regression analysis accounting for age, sex and cardiovascular risk factors was performed to compare the likelihood of myocardial injury [defined as elevation of cT<\/jats:styled-content>n\u00a0>\u00a099th percentile (\u226514\u00a0ng\/L); highly sensitive cardiac troponin T assay] in TGA<\/jats:styled-content> with three reference groups: migraine with aura, vestibular neuritis and transient ischaemic attack (TIA).<\/jats:p><\/jats:sec>Results<\/jats:title>Cardiac troponin<\/jats:styled-content> elevation occurred in 28 (25%) of 113 patients with TGA<\/jats:styled-content>. Patients with TGA<\/jats:styled-content> with cT<\/jats:styled-content>n elevation were significantly older, more likely to be female and had higher blood pressure on admission compared with those without. The likelihood of myocardial injury following TGA<\/jats:styled-content> was at least more than twofold higher compared with all three reference groups [adjusted odds ratio, 5.5; 95% confidence interval (CI<\/jats:styled-content>), 1.2\u201326.4, compared with migraine with aura; adjusted odds ratio, 2.2; 95% CI<\/jats:styled-content>, 1.2\u20134.4, compared with vestibular neuritis; adjusted odds ratio, 2.3; 95% CI<\/jats:styled-content>, 1.3\u20134.2, compared with TIA].<\/jats:p><\/jats:sec>Conclusions<\/jats:title>One out of four patients with TGA<\/jats:styled-content> had evidence of myocardial injury as assessed by highly sensitive cT<\/jats:styled-content>n assays. The likelihood of myocardial injury associated with TGA<\/jats:styled-content> was even higher than in TIA<\/jats:styled-content> patients with a more pronounced cardiovascular risk profile. Our findings suggest the presence of a TGA<\/jats:styled-content>\u2010related disturbance of brain\u2013heart interaction that deserves further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13920","type":"journal-article","created":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T01:14:32Z","timestamp":1548983672000},"page":"986-991","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Myocardial injury in transient global amnesia: a case\u2010control study"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5383-9625","authenticated-orcid":false,"given":"H.","family":"Erdur","sequence":"first","affiliation":[{"name":"Department of Neurology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Berlin"},{"name":"Berlin Institute of Health (BIH) Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Siegerink","sequence":"additional","affiliation":[{"name":"Center for Stroke Research Berlin Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Ganeshan","sequence":"additional","affiliation":[{"name":"Department of Neurology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. J.","family":"Audebert","sequence":"additional","affiliation":[{"name":"Department of Neurology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Berlin"},{"name":"Center for Stroke Research Berlin Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Endres","sequence":"additional","affiliation":[{"name":"Department of Neurology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Berlin"},{"name":"Berlin Institute of Health (BIH) Berlin"},{"name":"Center for Stroke Research Berlin Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Berlin"},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Berlin Berlin"},{"name":"DZNE (German Center for Neurodegenerative Diseases), Partner Site Berlin Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. H.","family":"Nolte","sequence":"additional","affiliation":[{"name":"Department of Neurology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Berlin"},{"name":"Berlin Institute of Health (BIH) Berlin"},{"name":"Center for Stroke Research Berlin Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Berlin"},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Berlin Berlin"},{"name":"DZNE (German Center for Neurodegenerative Diseases), Partner Site Berlin Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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