{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T22:49:44Z","timestamp":1778107784591,"version":"3.51.4"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,5,17]],"date-time":"2019-05-17T00:00:00Z","timestamp":1558051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Parkinson disease (PD) patients are classically classified according to two alternative motor subtyping methods: (i) tremor\u2010dominant versus postural instability and gait disorder; (ii) tremor\u2010dominant versus akinetic\u2010rigid. The degree of overlap between the two classification systems at diagnosis of <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> and their temporal stability, as well as the correspondence between the two systems, were examined over a follow\u2010up period of 4\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Newly diagnosed, untreated <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> patients were classified as tremor\u2010dominant versus postural instability and gait disorder and tremor\u2010dominant versus akinetic\u2010rigid at baseline and after 2 and 4\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a poor overlap between the two classification systems at any time point and baseline subtype status could not predict 4\u2010year subtype membership. In fact, about half of our cohort shifted category during the first 2\u00a0years, regardless of the classification scheme adopted. A lower rate of shift was observed from 2\u2010 to 4\u2010year follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The two classical motor subtyping methods of <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> poorly overlap, which implies that a patient can be categorized as tremor\u2010dominant in one classification system but not in the other. Moreover, their temporal instability undermines their prognostic value in the early stage of <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13968","type":"journal-article","created":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T15:25:17Z","timestamp":1555341917000},"page":"1212-1218","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Comparing postural instability and gait disorder and akinetic\u2010rigid subtyping of Parkinson disease and their stability over time"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7800-7419","authenticated-orcid":false,"given":"R.","family":"Erro","sequence":"first","affiliation":[{"name":"Center for Neurodegenerative Disease \u2013 CEMAND Department of Medicine, Surgery and Dentistry \u2018Scuola Medica Salernitana\u2019 University of Salerno Baronissi (SA) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9025-137X","authenticated-orcid":false,"given":"M.","family":"Picillo","sequence":"additional","affiliation":[{"name":"Center for Neurodegenerative Disease \u2013 CEMAND Department of Medicine, Surgery and Dentistry \u2018Scuola Medica Salernitana\u2019 University of Salerno Baronissi (SA) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Amboni","sequence":"additional","affiliation":[{"name":"Center for Neurodegenerative Disease \u2013 CEMAND Department of Medicine, Surgery and Dentistry \u2018Scuola Medica Salernitana\u2019 University of Salerno Baronissi (SA) Italy"},{"name":"Institute of Diagnosis and Health IDC\u2010Hermitage Capodimonte Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Savastano","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliera Universitaria 'San Giovanni di Dio e Ruggi d'Aragona' Salerno Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Scannapieco","sequence":"additional","affiliation":[{"name":"Center for Neurodegenerative Disease \u2013 CEMAND Department of Medicine, Surgery and Dentistry \u2018Scuola Medica Salernitana\u2019 University of Salerno Baronissi (SA) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Cuoco","sequence":"additional","affiliation":[{"name":"Center for Neurodegenerative Disease \u2013 CEMAND Department of Medicine, Surgery and Dentistry \u2018Scuola Medica Salernitana\u2019 University of Salerno Baronissi (SA) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7728-852X","authenticated-orcid":false,"given":"G.","family":"Santangelo","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Campania Luigi Vanvitelli Caserta Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Vitale","sequence":"additional","affiliation":[{"name":"Institute of Diagnosis and Health IDC\u2010Hermitage Capodimonte Naples Italy"},{"name":"Department of Motor Sciences and Wellness University \u2018Parthenope\u2019 Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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