{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T08:21:20Z","timestamp":1780734080520,"version":"3.54.1"},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T00:00:00Z","timestamp":1559260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>A composite instrument able to rapidly and reliably assess the most relevant motor and non\u2010motor afflictions suffered by Parkinson's disease (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>) patients in a real world clinic setting is an unmet need. The recently validated <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> Composite Scale (<jats:styled-content style=\"fixed-case\">PDCS<\/jats:styled-content>) was designed to fulfil this gap as a quick, comprehensive <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> assessment. The objective of this study was extensive evaluation of the <jats:styled-content style=\"fixed-case\">PDCS<\/jats:styled-content>'s clinimetric properties using a large international sample.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a cross\u2010sectional study in which the <jats:styled-content style=\"fixed-case\">PDCS<\/jats:styled-content>, the Movement Disorder Society Unified Parkinson's Disease Rating Scale and the Clinical Impression of Severity Index for <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> were applied. Basic clinimetric attributes of the <jats:styled-content style=\"fixed-case\">PDCS<\/jats:styled-content> were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 776 <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> patients were included. The <jats:styled-content style=\"fixed-case\">PDCS<\/jats:styled-content> total score showed negligible floor and ceiling effects. Three factors (54.5% of the variance) were identified: factor 1 included motor impairment, fluctuations and disability; factor 2, non\u2010motor symptoms; and factor 3, tremor and complications of therapy. Cronbach's alpha was from 0.66 to 0.79. Inter\u2010rater reliability showed weighted kappa values from 0.79 to 0.98 for items and intraclass correlation coefficient values from 0.95 (Disability) to 0.99 (Motor and total score). The Bland\u2013Altmann method, however, showed irregular concordance. <jats:styled-content style=\"fixed-case\">PDCS<\/jats:styled-content> standard error of measurement and convergent validity with equivalent constructs of other measures were satisfactory (\u22650.70). <jats:styled-content style=\"fixed-case\">PDCS<\/jats:styled-content> scores significantly differed by Hoehn and Yahr stage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Overall, in line with previous findings, the <jats:styled-content style=\"fixed-case\">PDCS<\/jats:styled-content> is a feasible, acceptable, valid, reliable and precise instrument for quickly and comprehensively assessing <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13976","type":"journal-article","created":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T11:26:58Z","timestamp":1556191618000},"page":"1281-1288","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Extensive validation study of the Parkinson's Disease Composite Scale"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0837-5280","authenticated-orcid":false,"given":"P.","family":"Martinez\u2010Martin","sequence":"first","affiliation":[{"name":"National Center of Epidemiology Carlos III Institute of Health Madrid Spain"},{"name":"Center for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED) Carlos III Institute of Health Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. G.","family":"Radicati","sequence":"additional","affiliation":[{"name":"University and Institute for Research and Medical Care IRCCS San Raffaele Roma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Rodriguez Blazquez","sequence":"additional","affiliation":[{"name":"National Center of Epidemiology Carlos III Institute of Health Madrid Spain"},{"name":"Center for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED) Carlos III Institute of Health Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Wetmore","sequence":"additional","affiliation":[{"name":"National Center of Epidemiology Carlos III Institute of Health Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Kovacs","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical School University of Pecs Pecs Hungary"},{"name":"MTA\u2010PTE Clinical MRI Research Group Pecs 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