{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:49:17Z","timestamp":1787014157178,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T00:00:00Z","timestamp":1559260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2019,10]]},"abstract":"\n Background and purpose<\/jats:title>\n \n Ischaemic stroke frequently has a cardioembolic (\n CE<\/jats:styled-content>\n ) source. Clinical and echocardiographic parameters associated with\n CE<\/jats:styled-content>\n stroke were evaluated.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n In all, 93 consecutive ischaemic stroke patients who underwent a transthoracic echocardiogram were retrospectively analysed; strokes were classified by\n TOAST<\/jats:styled-content>\n (Trial of Org 10172 in Acute Stroke Treatment) criteria. Echocardiographic parameters related to CE stroke, including left atrial volumes and function, were compared to 73 healthy controls.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of 93 patients (mean age 66.1\u00a0years, 56% male), nine (10%) had large artery atherosclerosis, 38 (41%)\n CE<\/jats:styled-content>\n stroke, two (2%) small vessel disease, two (2%) other and 42 (45%) undetermined aetiology. Left atrial (\n LA<\/jats:styled-content>\n ) maximum volumes (\n LAVI<\/jats:styled-content>\n max<\/jats:sub>\n ) and minimum volumes (\n LAVI<\/jats:styled-content>\n min<\/jats:sub>\n ) were larger in the\n CE<\/jats:styled-content>\n group than the non\u2010\n CE<\/jats:styled-content>\n group (45 vs. 32\u00a0ml\/m\n 2<\/jats:sup>\n , 32 vs. 13\u00a0ml\/m\n 2<\/jats:sup>\n , respectively,\n P<\/jats:italic>\n \u00a0<\u00a00.001), whilst\n LA<\/jats:styled-content>\n function indices including\n LA<\/jats:styled-content>\n emptying fraction and\n LA<\/jats:styled-content>\n function index (\n LAFI<\/jats:styled-content>\n ) were lower in the\n CE<\/jats:styled-content>\n group (34% vs. 55%, and 0.12 vs. 0.35, respectively,\n P<\/jats:italic>\n \u00a0<\u00a00.001). Adjusting for clinical characteristics,\n LAFI<\/jats:styled-content>\n \u22640.3 was an independent predictor of\n CE<\/jats:styled-content>\n stroke (adjusted odds ratio 5.3,\n P<\/jats:italic>\n \u00a0=\u00a00.001). Additionally,\n LAVI<\/jats:styled-content>\n max<\/jats:sub>\n and\n LAVI<\/jats:styled-content>\n min<\/jats:sub>\n were larger (61 vs. 44 and 32 vs. 24\u00a0ml\/m\n 2<\/jats:sup>\n respectively,\n P<\/jats:italic>\n \u00a0<\u00a00.01) and\n LAFI<\/jats:styled-content>\n significantly lower (0.34 vs. 0.52,\n P<\/jats:italic>\n \u00a0<\u00a00.001) in the undetermined aetiology group versus healthy controls.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Left atrial enlargement with reduced\n LA<\/jats:styled-content>\n function was associated with\n CE<\/jats:styled-content>\n stroke and\n LAFI<\/jats:styled-content>\n was the best independent predictor.\n LA<\/jats:styled-content>\n parameters were also altered in the undetermined aetiology group, suggesting an underlying\n LA<\/jats:styled-content>\n myopathy in this subset.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ene.13981","type":"journal-article","created":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T03:21:12Z","timestamp":1557199272000},"page":"1310-1317","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Clinical and echocardiographic characteristics of cardioembolic stroke"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6686-865X","authenticated-orcid":false,"given":"A.","family":"Ferkh","sequence":"first","affiliation":[{"name":"University of Sydney Camperdown NSW Australia"},{"name":"Cardiology Department Westmead Hospital Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Brown","sequence":"additional","affiliation":[{"name":"Cardiology Department Westmead Hospital Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"O'Keefe","sequence":"additional","affiliation":[{"name":"Cardiology Department Westmead Hospital Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3934-687X","authenticated-orcid":false,"given":"M.","family":"Zada","sequence":"additional","affiliation":[{"name":"Cardiology Department Westmead Hospital Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Duggins","sequence":"additional","affiliation":[{"name":"Neurology Department Westmead Hospital Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Thiagalingam","sequence":"additional","affiliation":[{"name":"University of Sydney Camperdown NSW Australia"},{"name":"Cardiology Department Westmead Hospital Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Altman","sequence":"additional","affiliation":[{"name":"Cardiology Department Westmead Hospital Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Boyd","sequence":"additional","affiliation":[{"name":"University of Sydney Camperdown NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Byth","sequence":"additional","affiliation":[{"name":"University of Sydney Camperdown NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Kizana","sequence":"additional","affiliation":[{"name":"University of Sydney Camperdown NSW Australia"},{"name":"Cardiology Department Westmead Hospital Sydney NSW Australia"},{"name":"Westmead Institute of Medical Research Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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