{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:04:44Z","timestamp":1747184684599,"version":"3.40.5"},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,7,12]],"date-time":"2019-07-12T00:00:00Z","timestamp":1562889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771393"],"award-info":[{"award-number":["81771393"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission","doi-asserted-by":"publisher","award":["Z171100001017125"],"award-info":[{"award-number":["Z171100001017125"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>The aim was to determine the electroclinical findings in benign childhood focal epilepsy with vertex spikes (<jats:styled-content style=\"fixed-case\">BEVS<\/jats:styled-content>) with epileptic negative myoclonus (<jats:styled-content style=\"fixed-case\">ENM<\/jats:styled-content>) restricted to the lower limbs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The electroencephalogram database of Peking University First Hospital and medical records of patients with <jats:styled-content style=\"fixed-case\">BEVS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ENM<\/jats:styled-content> restricted to the lower limbs were reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010seven patients with <jats:styled-content style=\"fixed-case\">BEVS<\/jats:styled-content> had <jats:styled-content style=\"fixed-case\">ENM<\/jats:styled-content> restricted to the lower limbs. Twelve started as <jats:styled-content style=\"fixed-case\">ENM<\/jats:styled-content> restricted to the lower limbs. The age at seizure onset ranged from 1.5 to 4.8\u00a0years. During the course, half of the 12 patients developed focal sensorimotor seizures and then were diagnosed as benign childhood epilepsy with centrotemporal spikes (<jats:styled-content style=\"fixed-case\">BECTS<\/jats:styled-content>), with <jats:styled-content style=\"fixed-case\">BEVS<\/jats:styled-content> (four cases) and without <jats:styled-content style=\"fixed-case\">BEVS<\/jats:styled-content> (two cases). Five of them had electrical status epilepticus during sleep (ESES)\u00a0and met the diagnostic criteria of atypical benign partial epilepsy (<jats:styled-content style=\"fixed-case\">ABPE<\/jats:styled-content>). Fifteen of the 27 patients had <jats:styled-content style=\"fixed-case\">ENM<\/jats:styled-content> restricted to the lower limbs during the course. The age at seizure onset ranged from 1.3 to 9.8\u00a0years. All had ESES and were diagnosed as <jats:styled-content style=\"fixed-case\">ABPE<\/jats:styled-content>, 11 as <jats:styled-content style=\"fixed-case\">ABPE<\/jats:styled-content> with <jats:styled-content style=\"fixed-case\">BEVS<\/jats:styled-content> and four as <jats:styled-content style=\"fixed-case\">ABPE<\/jats:styled-content> evolving into <jats:styled-content style=\"fixed-case\">BEVS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Benign childhood focal epilepsy with vertex spikes (BEVS)\u00a0might represent a specific epileptic syndrome of the continuum of benign childhood focal epilepsy. <jats:styled-content style=\"fixed-case\">ENM<\/jats:styled-content> restricted to the lower limbs was a special phenomenon in <jats:styled-content style=\"fixed-case\">BEVS<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">BEVS<\/jats:styled-content> could overlap with <jats:styled-content style=\"fixed-case\">BECTS<\/jats:styled-content> or evolve into <jats:styled-content style=\"fixed-case\">BECTS<\/jats:styled-content> and further into <jats:styled-content style=\"fixed-case\">ABPE<\/jats:styled-content> and vice versa. Ignorance of vertex spikes with associated <jats:styled-content style=\"fixed-case\">ENM<\/jats:styled-content> restricted to the lower limbs might lead to a misunderstanding of <jats:styled-content style=\"fixed-case\">BEVS<\/jats:styled-content>, a specific type of benign childhood focal epilepsy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13982","type":"journal-article","created":{"date-parts":[[2019,5,11]],"date-time":"2019-05-11T13:42:50Z","timestamp":1557582170000},"page":"1318-1326","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Epileptic negative myoclonus restricted to lower limbs in benign childhood focal epilepsy with vertex spikes"],"prefix":"10.1111","volume":"26","author":[{"given":"P.","family":"Gong","sequence":"first","affiliation":[{"name":"Department of Pediatrics Peking University First Hospital Beijing 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