{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:36:27Z","timestamp":1790008587080,"version":"4.0.1"},"reference-count":17,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T00:00:00Z","timestamp":1562025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001003","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001003","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background and purpose<\/jats:title>\n                    <jats:p>Data suggest a relationship between sexual dysfunction, mainly erectile dysfunction in men, and worse disease progression in Parkinson's disease (PD). There is scant evidence on the correlates of sexual activity in PD patients. By involving a subgroup of 355 patients from the PRIAMO (Parkinson Disease Non Motor Symptoms) study, the present 24\u2010month longitudinal prospective analysis aims to demonstrate that the presence of active sexual life is associated with disease progression in early PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      Multivariable mixed\u2010effect logistic regression models showed that gastrointestinal symptoms [odds ratio 0.56, 95% confidence interval (CI) 0.39\u20130.82,\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\u00a00.003] and apathy (odds ratio 0.42, 95% CI 0.29\u20130.63,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) were less likely to be associated with sexual activity in men. Analysis also demonstrated that sexual activity in men was associated with lower motor disability (coefficient \u22122.881, 95% CI \u22124.732 to \u22121.030,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.002), better quality of life (coefficient \u221224.196, 95% CI \u221244.884 to \u22123.508,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.022; coefficient 0.083, 95% CI 0.023\u20130.143,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.006) and lower depression scores (coefficient \u22121.245, 95% CI \u22122.104 to \u22120.387,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.004). No association was shown in women.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This is the first prospective longitudinal study involving a large cohort of PD patients suggesting that sexual activity is associated with lower motor and non\u2010motor disability as well as with better quality of life in men. These findings should prompt movement disorders specialists to periodically inquiry about their patients\u2019 sexual life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.13983","type":"journal-article","created":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T00:01:28Z","timestamp":1562112088000},"page":"1327-1333","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["The PRIAMO study: active sexual life is associated with better motor and non\u2010motor outcomes in men with early Parkinson's disease"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9025-137X","authenticated-orcid":false,"given":"M.","family":"Picillo","sequence":"first","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry, Neuroscience Section Center for Neurodegenerative Diseases (CEMAND) University of Salerno Salerno Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Palladino","sequence":"additional","affiliation":[{"name":"Department of Primary Care and Public Health School of Public Health Imperial College of London London UK"},{"name":"Department of Public Health School of Medicine University \u2018Federico II\u2019 Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7800-7419","authenticated-orcid":false,"given":"R.","family":"Erro","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry, Neuroscience Section Center for Neurodegenerative Diseases (CEMAND) University of Salerno Salerno Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Colosimo","sequence":"additional","affiliation":[{"name":"Department of Neurology Santa Maria University Hospital Terni Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Marconi","sequence":"additional","affiliation":[{"name":"Neurology Division Misericordia Hospital Grosseto Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1040-2807","authenticated-orcid":false,"given":"A.","family":"Antonini","sequence":"additional","affiliation":[{"name":"Department of Neurosciences (DNS) Padova University Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Barone","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry, Neuroscience Section Center for Neurodegenerative Diseases (CEMAND) University of Salerno Salerno Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the PRIAMO study group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2009.01621.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2014.07.003"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1353-8020(01)00042-6"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067423"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.12561"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2014.11.003"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-008-0863-z"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22643"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13290"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-012-6557-8"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.56.1.33"},{"key":"e_1_2_7_13_1","unstructured":"World Health Organization(2002).Defining sexual health: report on technical consultation on sexual health (p. 4).http:\/\/www.who.int\/reproductivehealth\/publications\/sexual_health\/defining_sexual_health.pdfaccessed 2018."},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-013-7085-x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2014.04.023"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-016-8384-9"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21596"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2015.02.015"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fene.13983","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.13983","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ene.13983","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.13983","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T18:46:00Z","timestamp":1694285160000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.13983"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,2]]},"references-count":17,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1111\/ene.13983"],"URL":"https:\/\/doi.org\/10.1111\/ene.13983","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,2]]},"assertion":[{"value":"2019-01-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}