{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:20:32Z","timestamp":1788877232606,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T00:00:00Z","timestamp":1562198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>In Parkinson's disease (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>), the course of the disorder is highly variable between patients. Well\u2010designed, prospective studies for identifying <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> progression biomarkers are necessary. Our aim was to show the results of baseline evaluations of an ongoing global <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> project, <jats:styled-content style=\"fixed-case\">COPPADIS<\/jats:styled-content>\u20102015 (<jats:styled-content style=\"fixed-case\">Co<\/jats:styled-content>hort of Patients with <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>rkinson's <jats:styled-content style=\"fixed-case\">DI<\/jats:styled-content>sease in Spain, 2015).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was an observational, descriptive, nationwide study (Spain). The recruitment period ended in October 2017. Baseline evaluation included more than 15 validated scales and complementary studies in a subgroup of participants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 1174 subjects from 35 centres were considered valid for baseline analysis: 694 patients (62.6\u00a0\u00b1\u00a08.9\u00a0years old, 60.3% males), 273 caregivers (58.5\u00a0\u00b1\u00a011.9\u00a0years old, 31.8% males) and 207 controls (61\u00a0\u00b1\u00a08.3\u00a0years old, 49.5% males). The mean disease duration was 5.5\u00a0\u00b1\u00a04.4\u00a0years. Hoehn and Yahr stage was 1 or 2 in 90.7% of the patients whilst 33.9% and 18.1% of them presented motor fluctuations and dyskinesias, respectively. The mean Non\u2010Motor Symptoms Scale total score was 45.4\u00a0\u00b1\u00a038.1, and 30.4% of the patients presented cognitive impairment, 16.1% major depression, 12.7% impulse control disorder, 7.2% compulsive behaviour, 57.2% pain and 13.2% falls. Compared to the control group, <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> patients presented a significantly higher burden of non\u2010motor symptoms and a worse quality of life. More than 300 subjects conducted complementary studies (serum biomarkers, genetic and neuroimaging).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Parkinson's disease is a complex disorder and different non\u2010motor symptoms are frequently present and are more prevalent than in controls. In real clinical practice it is important to ask for them.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.14008","type":"journal-article","created":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T03:44:22Z","timestamp":1560138262000},"page":"1399-1407","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["<scp>COPPADIS<\/scp>\u20102015 (<scp>CO<\/scp>hort of Patients with PArkinson's <scp>DI<\/scp>sease in Spain, 2015): an ongoing global Parkinson's disease project about disease progression with more than 1000 subjects included. Results from the baseline evaluation"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3126-5111","authenticated-orcid":false,"given":"D.","family":"Santos Garc\u00eda","sequence":"first","affiliation":[{"name":"CHUAC, Complejo Hospitalario Universitario de A Coru\u00f1a A Coru\u00f1a Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Jes\u00fas","sequence":"additional","affiliation":[{"name":"Hospital Universitario Virgen del Roc\u00edo Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Aguilar","sequence":"additional","affiliation":[{"name":"Hospital Universitari Mutua de Terrassa Terrassa Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. 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