{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T12:00:37Z","timestamp":1780488037074,"version":"3.54.1"},"reference-count":8,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,7,18]],"date-time":"2019-07-18T00:00:00Z","timestamp":1563408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2019,12]]},"abstract":"Background and purpose<\/jats:title>Correct diagnosis of idiopathic inflammatory myopathies (IIM<\/jats:styled-content>) may prevent harm from both lack of treatment in IIM<\/jats:styled-content> patients and unnecessary treatment in non\u2010IIM<\/jats:styled-content> patients. However, it is unknown whether additional histopathological fascia examination may contribute to diagnosing IIM<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>Thirty\u2010two magnetic resonance imaging guided en bloc<\/jats:italic> biopsies from patients diagnosed with IIM<\/jats:styled-content> (except inclusion body myositis) from 2010 to 2017 were reviewed: dermatomyositis (DM<\/jats:styled-content>) (n<\/jats:italic>\u00a0=\u00a06), non\u2010specific\/overlap myositis (NM<\/jats:styled-content>\/OM<\/jats:styled-content>) (n<\/jats:italic>\u00a0=\u00a011), immune\u2010mediated necrotizing myopathy (n<\/jats:italic>\u00a0=\u00a012) and anti\u2010synthetase syndrome (n<\/jats:italic>\u00a0=\u00a03). Muscle biopsy specimens were examined according to the 2004 European Neuromuscular Centre (ENMC<\/jats:styled-content>) criteria. Fascia was subsequently examined for the presence of lymphocytic infiltrates. Isolated fascia involvement was defined as the presence of lymphocytic infiltrates in the fascia\/epimysium on histopathology in the absence of any ENMC<\/jats:styled-content> muscle histopathology\/immunohistochemistry criteria.<\/jats:p><\/jats:sec>Results<\/jats:title>One patient with DM<\/jats:styled-content> (17%) and one patient with NM<\/jats:styled-content>\/OM<\/jats:styled-content> (9%) had isolated fascia involvement. One patient with immune\u2010mediated necrotizing myopathy (8%) and one patient with anti\u2010synthetase syndrome (33%) had fascia involvement, albeit in combination with muscle involvement.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Histopathological fascia examination may contribute to early diagnosis of DM<\/jats:styled-content> and NM<\/jats:styled-content>\/OM<\/jats:styled-content> in a small proportion of patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.14027","type":"journal-article","created":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T19:33:23Z","timestamp":1561059203000},"page":"1494-1496","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Diagnostic value of additional histopathological fascia examination in idiopathic inflammatory myopathies"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7565-1954","authenticated-orcid":false,"given":"J.","family":"Lim","sequence":"first","affiliation":[{"name":"Department of Neurology Amsterdam UMC University of Amsterdam, Amsterdam Neuroscience Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0146-0776","authenticated-orcid":false,"given":"F.","family":"Eftimov","sequence":"additional","affiliation":[{"name":"Department of Neurology Amsterdam UMC University of Amsterdam, Amsterdam Neuroscience Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3658-2001","authenticated-orcid":false,"given":"J.","family":"Raaphorst","sequence":"additional","affiliation":[{"name":"Department of Neurology Amsterdam UMC University of Amsterdam, Amsterdam Neuroscience Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3542-3770","authenticated-orcid":false,"given":"E.","family":"Aronica","sequence":"additional","affiliation":[{"name":"Department of (Neuro)Pathology Amsterdam UMC University of Amsterdam, Amsterdam Neuroscience Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. J.","family":"van der Kooi","sequence":"additional","affiliation":[{"name":"Department of Neurology Amsterdam UMC University of Amsterdam, Amsterdam Neuroscience Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-014-7313-z"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1402225"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/101.5.661"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.24307"},{"key":"e_1_2_8_6_1","first-page":"2986","article-title":"Brief report: Power Doppler ultrasonography for detection of increased vascularity in the fascia: a potential early diagnostic tool in fasciitis of dermatomyositis","volume":"68","author":"Yoshida K","year":"2016","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27704"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2004.02.006"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.61.3.316"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fene.14027","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.14027","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ene.14027","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.14027","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T10:51:34Z","timestamp":1694256694000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.14027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,18]]},"references-count":8,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1111\/ene.14027"],"URL":"https:\/\/doi.org\/10.1111\/ene.14027","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,18]]},"assertion":[{"value":"2018-11-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}