{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:03:47Z","timestamp":1792605827562,"version":"4.5.0"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T00:00:00Z","timestamp":1565654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Considerable functional reorganization takes place in amyotrophic lateral sclerosis (ALS) in face of relentless structural degeneration. This study evaluates functional adaptation in <jats:styled-content style=\"fixed-case\">ALS<\/jats:styled-content> patients with lower motor neuron predominant (<jats:styled-content style=\"fixed-case\">LMN<\/jats:styled-content>p) and upper motor neuron predominant (<jats:styled-content style=\"fixed-case\">UMN<\/jats:styled-content>p) dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventeen <jats:styled-content style=\"fixed-case\">LMN<\/jats:styled-content>p ALS patients, 14 <jats:styled-content style=\"fixed-case\">UMN<\/jats:styled-content>p <jats:styled-content style=\"fixed-case\">ALS<\/jats:styled-content> patients and 14 controls participated in a functional magnetic resonance imaging study. Study\u2010group\u2010specific activation patterns were evaluated during preparation for a motor task. Connectivity analyses were carried out using the supplementary motor area (<jats:styled-content style=\"fixed-case\">SMA<\/jats:styled-content>), cerebellum and striatum as seed regions and correlations were explored with clinical measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Increased cerebellar, decreased dorsolateral prefrontal cortex and decreased <jats:styled-content style=\"fixed-case\">SMA<\/jats:styled-content> activation were detected in <jats:styled-content style=\"fixed-case\">UMN<\/jats:styled-content>p patients compared to controls. Increased cerebellar activation was also detected in <jats:styled-content style=\"fixed-case\">UMN<\/jats:styled-content>p patients compared to <jats:styled-content style=\"fixed-case\">LMN<\/jats:styled-content>p patients. <jats:styled-content style=\"fixed-case\">UMN<\/jats:styled-content>p patients exhibit increased effective connectivity between the cerebellum and caudate, and decreased connectivity between the <jats:styled-content style=\"fixed-case\">SMA<\/jats:styled-content> and caudate and between the <jats:styled-content style=\"fixed-case\">SMA<\/jats:styled-content> and cerebellum when performing self\u2010initiated movement. In <jats:styled-content style=\"fixed-case\">UMN<\/jats:styled-content>p patients, a positive correlation was detected between clinical variables and striato\u2010cerebellar connectivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings indicate that, despite the dysfunction of <jats:styled-content style=\"fixed-case\">SMA<\/jats:styled-content>\u2013striatal and <jats:styled-content style=\"fixed-case\">SMA<\/jats:styled-content>\u2013cerebellar networks, cerebello\u2010striatal connectivity increases in <jats:styled-content style=\"fixed-case\">ALS<\/jats:styled-content> indicative of compensatory processes. The coexistence of circuits with decreased and increased connectivity suggests concomitant neurodegenerative and adaptive changes in <jats:styled-content style=\"fixed-case\">ALS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.14042","type":"journal-article","created":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T14:18:12Z","timestamp":1563286692000},"page":"121-128","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":93,"title":["Adaptive functional reorganization in amyotrophic lateral sclerosis: coexisting degenerative and compensatory changes"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0833-4323","authenticated-orcid":false,"given":"M.","family":"Abidi","sequence":"first","affiliation":[{"name":"CeRSM Laboratory Nanterre University UPL Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"de 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