{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T07:51:23Z","timestamp":1792050683302,"version":"4.4.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T00:00:00Z","timestamp":1565654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007687","name":"Svenska L\u00e4kares\u00e4llskapet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007687","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005689","name":"G\u00f6teborgs L\u00e4kares\u00e4llskap","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005689","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006285","name":"Magnus Bergvalls Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006285","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background and purpose<\/jats:title>\n                    <jats:p>Data on epilepsy in dementia, particularly on its risk factors, are scarce. Confounding comorbidities and the rising incidence of epilepsy in older age have hampered studies in this field. The occurrence and risk factors for epilepsy in the Swedish Dementia Registry (SveDem), a large cohort of patients with dementia, have been examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Information on epilepsy and seizure\u2010related diagnoses, comorbidities and survival were extracted for all individuals in SveDem (\n                      <jats:italic>n\u00a0<\/jats:italic>\n                      =\n                      <jats:italic>\u00a0<\/jats:italic>\n                      81\u00a0192) and three randomly selected age\u2010 and gender\u2010matched controls from the population register, excluding all with\u00a0a dementia diagnosis (\n                      <jats:italic>n\u00a0<\/jats:italic>\n                      =\n                      <jats:italic>\u00a0<\/jats:italic>\n                      223\u00a0933). The risk of epilepsy following dementia diagnosis was estimated with Kaplan\u2013Meier curves, and Cox proportional hazard modelling was used to identify risk factors and adjust for comorbidities.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A diagnosis of epilepsy was found more frequently amongst dementia patients [4.0%, 95% confidence interval (\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      ) 3.8\u20134.1] than controls (1.9%, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      1.9\u20132.0). The risk of incident epilepsy after dementia was 2.1% (95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      1.9\u20132.3) at 5\u00a0years and 4.0% (95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      3.4\u20134.6) at 10\u00a0years, compared to 0.8% (95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      0.8\u20130.8) and 1.6% (95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      1.4\u20131.8) respectively for controls. The risk was greatest for early\u2010onset Alzheimer's disease. In multivariate analysis, dementia was associated with a hazard ratio of 2.52 (95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      2.31\u20132.74) for epilepsy. Young age, male sex, stroke, brain trauma, brain tumour and low\n                      <jats:styled-content style=\"fixed-case\">Mini\u2010Mental State Examination<\/jats:styled-content>\n                      score significantly increased the risk.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Dementia, particularly young\u2010onset Alzheimer's disease, increases the risk of subsequent epilepsy. Further studies are needed to determine optimal management and the impact of epilepsy on prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.14043","type":"journal-article","created":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T15:28:54Z","timestamp":1563809334000},"page":"129-135","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Increased risk of epilepsy in patients registered in the Swedish Dementia Registry"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9445-4545","authenticated-orcid":false,"given":"J.","family":"Zelano","sequence":"first","affiliation":[{"name":"Department of Clinical Neuroscience Institute of Neuroscience and Physiology Sahlgrenska Academy Gothenburg University Gothenburg Sweden"},{"name":"Department of Neurology Sahlgrenska University Hospital Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0928-1577","authenticated-orcid":false,"given":"F.","family":"Brigo","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Biomedicine and Movement Science University of Verona Verona Italy"},{"name":"Division of Neurology \u2018Franz Tappeiner\u2019 Hospital Merano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Garcia\u2010Patek","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Care Sciences and Society Division of Clinical Geriatrics Karolinska Institutet Stockholm Sweden"},{"name":"Internal Medicine Section for Neurology S\u00f6dersjukhuset Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004740"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13709"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.3.727"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13744"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2009.130"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12045"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.5698\/1535-7511-12.5.184"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq033"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0116538"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2011.03121.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004094"},{"key":"e_1_2_7_13_1","first-page":"303","volume-title":"Epilepsy. Neuroepidemiology From Principles to Practice","author":"Annegers JF","year":"2004"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-170031"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2011-110200"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25157"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2011.830"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1992.tb02343.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/089198879400700407"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2009.15"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2017.09.026"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2013.06.005"},{"key":"e_1_2_7_23_1","first-page":"314","article-title":"Differences in diagnostic process, treatment and social support for Alzheimer's dementia between primary and specialist care: results from the Swedish Dementia Registry","volume":"46","author":"Garcia\u2010Ptacek S","year":"2017","journal-title":"Age Ageing"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)15946-1"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2017.05.010"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fene.14043","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.14043","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ene.14043","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.14043","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T06:02:14Z","timestamp":1694239334000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.14043"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,13]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1111\/ene.14043"],"URL":"https:\/\/doi.org\/10.1111\/ene.14043","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,13]]},"assertion":[{"value":"2019-04-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}