{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T16:58:01Z","timestamp":1781974681650,"version":"3.54.5"},"reference-count":6,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T00:00:00Z","timestamp":1565568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"Background and purpose<\/jats:title>Thymectomy is an effective treatment for myasthenia gravis (MG<\/jats:styled-content>) with anti\u2010acetylcholine receptor (AC<\/jats:styled-content>hR) antibodies. We rarely encounter patients who develop MG<\/jats:styled-content> after surgery for thymic tumors. This study aimed to investigate the characteristics and frequency of post\u2010thymectomy onset (PostTx) MG<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>We reviewed the clinical information of thymoma\u2010associated MG<\/jats:styled-content> in 158 patients. Of these, 18 (11%) patients with PostTx MG<\/jats:styled-content> were identified.<\/jats:p><\/jats:sec>Results<\/jats:title>The presence of anti\u2010AC<\/jats:styled-content>hR antibodies (82%) and electrophysiological abnormalities (50%) was confirmed before thymectomy in patients with PostTx MG<\/jats:styled-content>. The clinical characteristics of PostTx MG<\/jats:styled-content> were similar to those of pre\u2010thymectomy onset (PreTx) MG. In PostTx MG<\/jats:styled-content>, the duration between thymectomy and MG<\/jats:styled-content> onset were distributed as\u00a0<\u00a06\u00a0months (early\u2010onset PostTx MG<\/jats:styled-content>) and\u00a0\u2265\u00a06\u00a0months (late\u2010onset PostTx MG<\/jats:styled-content>). Notably, some patients with late\u2010onset PostTx MG<\/jats:styled-content> were associated with thymoma relapse.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Our results suggest that approximately 11% of patients with thymoma\u2010associated MG<\/jats:styled-content> were PostTx MG<\/jats:styled-content> and pre\u2010surgical assessment of anti\u2010AC<\/jats:styled-content>hR antibody titer or electrophysiological testing may predict PostTx MG<\/jats:styled-content> development. However, no difference in clinical manifestation and prognosis was observed between PreTx MG<\/jats:styled-content> and PostTx MG<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.14052","type":"journal-article","created":{"date-parts":[[2019,7,26]],"date-time":"2019-07-26T06:53:38Z","timestamp":1564124018000},"page":"175-180","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Frequency and features of myasthenia gravis developing after thymectomy"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9252-1863","authenticated-orcid":false,"given":"A.","family":"Uzawa","sequence":"first","affiliation":[{"name":"Department of Neurology Graduate School of Medicine Chiba University Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Kanai","sequence":"additional","affiliation":[{"name":"Department of Neurology Graduate School of Medicine Chiba University Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Oda","sequence":"additional","affiliation":[{"name":"Department of Neurology Graduate School of Medicine Chiba University Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Ozawa","sequence":"additional","affiliation":[{"name":"Department of Neurology Graduate School of Medicine Chiba University Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of Neurology Graduate School of Medicine Chiba University Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Kawaguchi","sequence":"additional","affiliation":[{"name":"Department of Neurology Graduate School of Medicine Chiba University Chiba Japan"},{"name":"Department of Neurology Neurology Chiba Clinic Chiba 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