{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T19:40:22Z","timestamp":1790970022107,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T00:00:00Z","timestamp":1569369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Muscle\u2010strengthening, stretching or proprioceptive treatments may slow symptom progression in Charcot\u2014Marie\u2013Tooth (<jats:styled-content style=\"fixed-case\">CMT<\/jats:styled-content>) neuropathy. The aim of the study was to evaluate safety and efficacy of treadmill training in <jats:styled-content style=\"fixed-case\">CMT<\/jats:styled-content>1A.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We planned a multicenter, prospective, randomized, single\u2010blind, controlled study. We recruited 53 outpatients affected by <jats:styled-content style=\"fixed-case\">CMT<\/jats:styled-content>1A and randomized them into two treatment groups: one underwent stretching and proprioceptive exercise, whereas the other was additionally treated with treadmill training (Tre<jats:styled-content style=\"fixed-case\">SPE<\/jats:styled-content>). Primary outcome measures (<jats:styled-content style=\"fixed-case\">OMs<\/jats:styled-content>) were the walking evaluations and secondary <jats:styled-content style=\"fixed-case\">OM<\/jats:styled-content> was the balance assessment. All participants were assessed at baseline and after 3 and 6\u00a0months of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Most patients showed an improvement in at least one <jats:styled-content style=\"fixed-case\">OM<\/jats:styled-content> after 3\u00a0months [42\/47 (89.4%)] and 6\u00a0months [38\/40 (95%)] of treatment. No adverse events were reported in either group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The most important finding was that both stretching and proprioceptive exercise and treadmill training had an objective benefit on patients affected by <jats:styled-content style=\"fixed-case\">CMT<\/jats:styled-content> disease, without causing overwork weakness. We had a low rate of drop out and did not find deterioration in motor performance. Our results also confirm that applying evidence\u2010based medicine methods to rehabilitative research is the correct way to test the efficacy of a treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.14074","type":"journal-article","created":{"date-parts":[[2019,8,24]],"date-time":"2019-08-24T13:14:08Z","timestamp":1566652448000},"page":"280-287","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Treadmill training in patients affected by Charcot\u2013Marie\u2013Tooth neuropathy: results of a multicenter, prospective, randomized, single\u2010blind, controlled study"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2762-8327","authenticated-orcid":false,"given":"L.","family":"Mori","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health University of Genoa Genoa Italy"},{"name":"IRCCS Ospedale Policlinico San Martino Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6289-9144","authenticated-orcid":false,"given":"A.","family":"Signori","sequence":"additional","affiliation":[{"name":"Department of Health Science Biostatistics Section University of Genoa Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Prada","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health University of Genoa Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Pareyson","sequence":"additional","affiliation":[{"name":"Fondazione IRCCS Istituto Neurologico Carlo Besta Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Piscosquito","sequence":"additional","affiliation":[{"name":"Functional Neuromotor Rehabilitation Unit IRCCS \u2018ICS Maugeri Spa \u2013 SB\u2019 Scientific Institute of Telese Terme Telese Terme Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Padua","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Neurosciences and Orthopedics Catholic University of Sacred Heart Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Pazzaglia","sequence":"additional","affiliation":[{"name":"Fondazione Don Carlo Gnocchi Onlus Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. M.","family":"Fabrizi","sequence":"additional","affiliation":[{"name":"Neurology Section Department of Neuroscience, Biomedicine and Movement Sciences University of Verona Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Picelli","sequence":"additional","affiliation":[{"name":"Neuromotor and Cognitive Rehabilitation Research Center Department of Neurosciences, Biomedicine and Movement Sciences University of Verona Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Schenone","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health University of Genoa Genoa Italy"},{"name":"IRCCS Ospedale Policlinico San Martino Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"TreSPE study group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jns.12116"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2014.07.006"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2340\/16501977-1071"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000003278"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2014.09.013"},{"key":"e_1_2_8_7_1","first-page":"7","article-title":"Management of Charcot\u2010Marie\u2010Tooth disease: improving long\u2010term care with a multidisciplinary approach","volume":"9","author":"McCorquodale D","year":"2016","journal-title":"J Multidiscip Healthc"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70025-4"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.23736\/S1973-9087.18.05111-0"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13033"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2007.09.006"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2013.07.007"},{"key":"e_1_2_8_13_1","first-page":"1215","article-title":"Phrenic nerve involvement in Charcot\u2010Marie\u2010Tooth","volume":"18","author":"Carter GT","year":"1995","journal-title":"Muscle Nerve"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9993(02)04949-3"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2003.12.025"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jns.12100"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20959"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.14074","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ene.14074","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.14074","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T08:08:07Z","timestamp":1694160487000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.14074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,25]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1111\/ene.14074"],"URL":"https:\/\/doi.org\/10.1111\/ene.14074","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,25]]},"assertion":[{"value":"2019-03-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}